| Atrial pronatriodilatin: a precursor for natriuretic factor and cardiodilatin. Amino acid sequence evidence. | |
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MedLine Citation:
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PMID: 6547393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Numerous peptides isolated from rat heart atria, including two containing 33 and 73 amino acids, were isolated and shown to exhibit natriuretic activities. Here, we describe the purification and partial amino acid sequence of a 106-residue peptide containing the previously sequenced 33- and 73-amino-acid ANF peptides. The determined sequence is a novel one and is not significantly homologous to any known protein or segment thereof. In fact, this sequence shows significant homology only to another novel partial sequence obtained from sequence analysis of a porcine peptide, called cardiodilatin, also found in heart atria. This relationship is taken as evidence that ANF and cardiodilatin are part of the same precursor molecule which would contain at the very least 126 amino acids. |
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Authors:
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C Lazure; N G Seidah; M Chrétien; G Thibault; R Garcia; M Cantin; J Genest |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: FEBS letters Volume: 172 ISSN: 0014-5793 ISO Abbreviation: FEBS Lett. Publication Date: 1984 Jun |
Date Detail:
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Created Date: 1984-08-08 Completed Date: 1984-08-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0155157 Medline TA: FEBS Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 80-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Atrial Natriuretic Factor Chickens Chromatography, Gel Female Heart Atria / analysis Muscle Proteins / analysis* Muscle, Smooth / drug effects Myocardium / analysis* Natriuresis / drug effects* Natriuretic Agents Protein Precursors / analysis* Proteins / analysis* Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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0/Muscle Proteins; 0/Natriuretic Agents; 0/Protein Precursors; 0/Proteins; 85637-73-6/Atrial Natriuretic Factor; 92047-08-0/cardiodilatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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