Document Detail

Atrial pressure and experimental atrial fibrillation.
MedLine Citation:
PMID:  7491311     Owner:  NLM     Status:  MEDLINE    
A possible profibrillatory effect on the atria of an elevated atrial pressure and the site of atrial stimulation was examined. In 15 anesthetized dogs, right or left atrial or biatrial pacing was applied at a high rate (300-600/min) for 5 seconds at double threshold intensity under a wide range of atrial pressures achieved by venous or arterial transfusion or bleeding. Induction of atrial fibrillation in 236 of 1,971 pacing runs was associated with a significantly higher (P < 0.001) atrial pressure (21.6 +/- 12.2 mmHg, mean +/- SD) than maintenance of sinus rhythm (16.8 +/- 11.1 mmHg in 1,735 of 1,971 pacing runs). Stimulation of the right atrium resulted in atrial fibrillation more frequently than left atrial or biatrial stimulation, with biatrial stimulation less frequent than right or left atrial stimulation. The induction of atrial fibrillation was related to the atrial pressure and to the site of stimulation but not to the pacing rate or the prepacing heart rate. The prepacing heart rate, associated with failure to induce sustained atrial fibrillation, was higher than that associated with atrial fibrillation in 12 of 15 experiments (significantly in 6) and not significantly lower in 3 of 15. Atrial fibrillation lasting 1 minute or more was more frequently associated with simultaneous stimulation of both atria than of either atrium alone. Thus, an elevated atrial pressure may facilitate the induction of atrial fibrillation. The site of stimulation also plays an important role for both the induction and maintenance of atrial fibrillation in this model.
D A Sideris; S T Toumanidis; E Tselepatiotis; K Kostopoulos; T Stringli; T Kitsiou; S D Moulopoulos
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  18     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-01-04     Completed Date:  1996-01-04     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1679-85     Citation Subset:  IM    
Department of Clinical Therapeutics, Medical School of Athens University, Greece.
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MeSH Terms
Atrial Fibrillation / etiology*,  physiopathology
Atrial Function*
Atrial Function, Left
Atrial Function, Right
Atrial Premature Complexes / etiology,  physiopathology
Blood Pressure*
Blood Transfusion
Blood Volume
Cardiac Pacing, Artificial / methods
Heart Rate

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