| Atrial natriuretic peptides during experimental atrial tachycardia: role of developing tachycardiomyopathy. | |
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MedLine Citation:
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PMID: 15333089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Atrial tachycardia and chronic heart failure (CHF) are associated with elevated levels of atrial natriuretic peptide (ANP) and its amino terminal part NT-ANP. Chronic high atrial rates may cause CHF due to a rapid ventricular response. The aim of this study was to establish the contribution of elevated atrial rate and of high ventricular rate, resulting in CHF, on ANP and NT-ANP levels during chronic atrial tachycardia. METHODS AND RESULTS: Thirteen goats (AV-paced group) were subjected to 4 weeks of rapid AV pacing with an atrial and ventricular rate of 240 beats/min. Another five goats (A-paced group) were subjected to 4 weeks of atrial pacing at 240 beats/min while the ventricular rate was kept low and regular at 80 beats/min. Pacing was interrupted only for measurement of right atrial (RA) and left ventricular (LV) diameter and sampling for ANP, NT-ANP, and renin. In the AV-paced group, RA and LV diameter reached 152% and 109% of baseline values, respectively. Both ANP and NT-ANP (8.3 +/- 9.2 pmol/L and 0.5 +/- 0.4 nmol/L at baseline, respectively) increased progressively (53.1 +/- 37.9 pmol/L and 2.0 +/- 0.9 nmol/L, respectively, after 4 weeks). There was a significant correlation between the magnitude of atrial dilation and natriuretic peptide levels after 3 days. In A-paced goats, however, RA and LV diameters did not change. Furthermore, ANP and NT-ANP levels (9.1 +/- 6.0 pmol/L and 0.8 +/- 0.2 nmol/L at baseline, respectively) were unchanged after 4 weeks (5.3 +/- 3.4 pmol/L and 0.6 +/- 0.2 nmol/L, respectively). CONCLUSION: Elevated levels of ANPs during chronic atrial tachycardia are related to a high ventricular rate rather than a high atrial rate alone. Rather than atrial tachycardia, the atrial hemodynamic burden is an important determinant of the sustained ANP response. |
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Authors:
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Bas A Schoonderwoerd; Harry J G M Crijns; Dirk J van Veldhuisen; Frans Boomsma; Maarten P van den Berg; Klaas J Bel; Isabelle C van Gelder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of cardiovascular electrophysiology Volume: 15 ISSN: 1045-3873 ISO Abbreviation: J. Cardiovasc. Electrophysiol. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-30 Completed Date: 2004-12-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9010756 Medline TA: J Cardiovasc Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 927-32 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Thoraxcenter, University Hospital Groningen, Groningen, The Netherlands. B.A.Schoonderwoerd@thorax.azg.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Atrial Natriuretic Factor / blood* Female Goats Heart Failure / blood*, diagnosis, etiology, physiopathology* Tachycardia, Ectopic Atrial / blood*, complications, diagnosis, physiopathology* Tachycardia, Ventricular / blood*, complications, physiopathology* |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
| Comments/Corrections | |
Comment In:
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J Cardiovasc Electrophysiol. 2004 Aug;15(8):933-5
[PMID:
15333090
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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