| Atrial natriuretic peptide stimulates lipid mobilization during repeated bouts of endurance exercise. | |
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MedLine Citation:
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PMID: 16291573 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrial natriuretic peptide (ANP) controls lipolysis in human adipocytes. Lipid mobilization is increased during repeated bouts of exercise, but the underlying mechanisms involved in this process have not yet been delineated. The relative involvement of catecholamine- and ANP-dependent pathways in the control of lipid mobilization during repeated bouts of exercise was thus investigated in subcutaneous adipose tissue (SCAT) by microdialysis. The study was performed in healthy males. Subjects performed two 45-min exercise bouts (E1 and E2) at 50% of their maximal oxygen uptake separated by a 60-min rest period. Extracellular glycerol concentration (EGC), reflecting SCAT lipolysis, was measured in a control probe perfused with Ringer solution and in two other probes perfused with either Ringer plus phentolamine (alpha(1/2)-AR antagonist) or Ringer plus both phentolamine and propranolol (beta-AR antagonist). Plasma epinephrine, plasma glycerol, and EGC were 1.7-, 1.6-, and 1.2-fold higher in E2 than in E1, respectively. Phentolamine potentiated exercise-induced EGC increase during E2 only. Propranolol reduced the lipolytic rate during both E1 and E2 compared with the probe with phentolamine. Plasma ANP concentration increased more during E2 than during E1 and was correlated with the increase in EGC in the probe containing phentolamine plus propranolol. The results suggest that ANP is involved in the control of lipolysis during exercise and that it contributes to stimulation of lipolysis during repeated bouts of exercise. |
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Authors:
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Cédric Moro; Jan Polak; Jindra Hejnova; Eva Klimcakova; François Crampes; Vladimir Stich; Max Lafontan; Michel Berlan |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-11-15 |
Journal Detail:
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Title: American journal of physiology. Endocrinology and metabolism Volume: 290 ISSN: 0193-1849 ISO Abbreviation: Am. J. Physiol. Endocrinol. Metab. Publication Date: 2006 May |
Date Detail:
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Created Date: 2006-04-10 Completed Date: 2006-06-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100901226 Medline TA: Am J Physiol Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: E864-9 Citation Subset: IM |
Affiliation:
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Franco-Czech Laboratory for Clinical Research on Obesity, French Institute of Health and Medical Research (INSERM U586), Toulouse, France. moro@cict.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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blood supply,
drug effects,
metabolism Adult Atrial Natriuretic Factor / blood*, physiology Blood Glucose / metabolism Catecholamines / blood Cyclic AMP / metabolism Cyclic GMP / metabolism Epinephrine / blood Exercise / physiology* Extracellular Fluid / drug effects, metabolism Fatty Acids, Nonesterified / blood Glycerol / blood, metabolism Growth Hormone / blood Heart Rate / physiology Humans Insulin / blood Lipolysis / physiology* Male Microdialysis Norepinephrine / blood Phentolamine / pharmacology Physical Endurance / physiology* Propranolol / pharmacology Regional Blood Flow / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Catecholamines; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 50-60-2/Phentolamine; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 525-66-6/Propranolol; 56-81-5/Glycerol; 60-92-4/Cyclic AMP; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; 9002-72-6/Growth Hormone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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