Document Detail


Atrial natriuretic peptide stimulates aldosterone production by turkey (Meleagris gallopavo) adrenal steroidogenic cells.
MedLine Citation:
PMID:  8536948     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The inhibitory action of atrial natriuretic peptides (ANPs) on mammalian aldosterone synthesis is well documented. In addition, other work indicates that ANP and an analogue of its second messenger, 8-Br-cGMP, inhibit aldosterone production by chicken adrenal steroidogenic cells. However, the interaction between angiotensin II (AII) and ANP in the regulation of avian aldosterone production is poorly understood because chicken adrenal steroidogenic cells, the commonly used in vitro avian model, are comparatively unresponsive to AII. By contrast, turkey (Meleagris gallopavo) adrenal steroidogenic cells are sensitive to AII. Thus, in the present study, the action of ANPs and related peptides and their interaction with other stimulators of aldosterone production were investigated using freshly isolated and briefly cultured turkey adrenal steroidogenic cells. Surprisingly, several ANPs [rat (r), human (h), chicken (c)], and rat brain natriuretic peptide (rBNP) were as efficacious as [Ile5]AII for stimulating aldosterone production (2 hr) in freshly isolated cell suspensions but were less potent than [Ile5]AII (ED50 of ANPs approximately 5-10 nM; [Ile5]AII ED50 approximately 0.1 nM). In addition, chicken ANP enhanced maximal aldosterone production induced by [Ile5]AII (1 nM), K+ (25 mM), and hACTH-(1-39) (ACTH) (1 nM): maximal enhancement of the action of these secretagogues was +49%, +137% and +15%, respectively (P < 0.05; n = 3). Furthermore, other ANPs and related peptides [rBNP and bovine aldosterone secretion inhibiting factor (bASIF)] enhanced maximal [Ile5]AII-induced aldosterone production: the order of maximal enhancement was rBNP (+180%) > hANP/rANP (+50%) > bASIF (+25%) (P < 0.05; n = 3).(ABSTRACT TRUNCATED AT 250 WORDS)
Authors:
J F Kocsis; P J McIlroy; R V Carsia
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  General and comparative endocrinology     Volume:  99     ISSN:  0016-6480     ISO Abbreviation:  Gen. Comp. Endocrinol.     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-07     Completed Date:  1996-02-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370735     Medline TA:  Gen Comp Endocrinol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  364-72     Citation Subset:  IM    
Affiliation:
Department of Cell Biology, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford 08084, USA.
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MeSH Terms
Descriptor/Qualifier:
Adrenal Glands / drug effects*,  metabolism
Aldosterone / biosynthesis*
Animals
Atrial Natriuretic Factor / pharmacology*
Cattle
Chickens
Cyclic GMP / biosynthesis
Evaluation Studies as Topic
Humans
Male
Rats
Receptors, Atrial Natriuretic Factor / drug effects
Stimulation, Chemical
Turkeys / metabolism*
Chemical
Reg. No./Substance:
52-39-1/Aldosterone; 7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor

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