| Atrial natriuretic peptide stability. | |
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MedLine Citation:
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PMID: 18539145 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Atrial natriuretic peptide (ANP) is a key regulator in the homeostasis of water excretion and has emerged as an important prognostic marker for symptomatic chronic heart failure (CHF). The stability of ANP represents a crucial factor in assessing its use as a cardiac biomarker. Accordingly, we assessed the stability of ANP in blood samples collected from healthy controls and CHF subjects for a 12 month period. METHODS: Blood samples from 10 healthy controls and 12 symptomatic CHF subjects with left ventricular systolic dysfunction were drawn. Determination of plasma ANP was performed by a standardized radioimmunoassay protocol. RESULTS: The ANP levels of healthy subjects were 68.5+/-11.6 pg/mL at baseline and 69.9+/-17.2 pg/mL at 12 months (p=0.71). The ANP concentrations of CHF subjects were 199.25+/-44.8 pg/mL at baseline and 197.83+/-47.4 pg/mL at 12 months (p=0.70) respectively. CONCLUSION: ANP is a stable molecule with no evidence of degradation when stored at -80 degrees C. |
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Authors:
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Ronald Zolty; Carol Bauer; Pamila Allen; Maureen Garrity; Timothy J Vittorio |
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Publication Detail:
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Type: Journal Article Date: 2008-05-27 |
Journal Detail:
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Title: Clinical biochemistry Volume: 41 ISSN: 1873-2933 ISO Abbreviation: Clin. Biochem. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-12-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0133660 Medline TA: Clin Biochem Country: United States |
Other Details:
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Languages: eng Pagination: 1255-8 Citation Subset: IM |
Affiliation:
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Albert Einstein College of Medicine, Division of Cardiology, Bronx, NY 10461, USA. RZOLTY@montefiore.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atrial Natriuretic Factor / blood* Case-Control Studies Chronic Disease Female Heart Failure / blood Humans Male Middle Aged Protein Stability Thermodynamics |
| Chemical | |
Reg. No./Substance:
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85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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