Document Detail

Atrial natriuretic peptide reverses angiotensin-induced venoconstriction in dogs.
MedLine Citation:
PMID:  2529779     Owner:  NLM     Status:  MEDLINE    
To determine whether atrial natriuretic peptide (ANP) can reverse angiotensin (ANG II)-induced venoconstriction, ANP was infused (0.3 in the presence of ANG II-induced hypertension in six ganglion-blocked dogs. ANG II was initially administered to increase mean arterial blood pressure (MAP) 50% above control. ANG II did not change heart rate or left ventricular rate of pressure development (LV dP/dt) but increased total peripheral vascular resistance (TPVR) and left ventricular end-diastolic pressure (LVEDP). Mean circulatory filling pressure (MCFP) increased, whereas cardiac output and venous compliance decreased. Unstressed vascular volume did not change, but central blood volume increased. ANP infusion during ANG II-induced hypertension resulted in a decrease in MAP, but TPVR did not change. There were no changes in heart rate or LV dP/dt. ANP decreased cardiac output further. LVEDP returned to base line with ANP. ANP also decreased MCFP and normalized venous compliance. There was no significant change in total blood volume, but central blood volume decreased. In summary, ANP can reverse the venoconstriction but not the arterial vasoconstriction produced by ANG II. The decrease in MAP was due to a decrease in cardiac output that resulted from venodilatation and aggravation of the preload-afterload mismatch produced by ANG II alone. Because TPVR did not change when MAP fell, we conclude that the interaction between ANG II and ANP occurs primarily in the venous circulation.
R W Lee; R G Gay; S Goldman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of physiology     Volume:  257     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-17     Completed Date:  1989-11-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  H1062-7     Citation Subset:  IM    
Department of Internal Medicine, Tucson Veterans Administration Medical Center, Arizona 85723.
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MeSH Terms
Angiotensin II / pharmacology*
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Cardiac Output / drug effects
Heart Rate / drug effects
Hemodynamics / drug effects*
Reference Values
Vascular Resistance / drug effects
Vasoconstriction / drug effects*
Veins / drug effects,  physiology
Grant Support
Reg. No./Substance:
11128-99-7/Angiotensin II; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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