Document Detail

Atrial natriuretic peptide response to postural changes and upright exercise in patients with venous valvular insufficiency.
MedLine Citation:
PMID:  8376908     Owner:  NLM     Status:  MEDLINE    
To investigate the effects of postural changes and upright exercise on atrial natriuretic peptide release and renin-angiotensin-aldosterone system behavior in patients with venous valvular insufficiency, plasma ANP, plasma renin activity and aldosterone were measured in 11 patients with venous disease and in 11 age-matched controls. In patients with large varicose veins and venous valvular dysfunction, standing was associated with a greater fall in circulating ANP levels (p < 0.05) and upright exercise was accompanied by a smaller rise in ANP concentrations (p < 0.05) as compared with controls. A significant (p < 0.001) inverse relationship was found between the number of venous segments with reflux and both upright and exercise plasma ANP concentrations (r = -0.91; r = -0.84, respectively). In the two groups the response of the renin-angiotensin-aldosterone system to upright position and physical stress was similar. These results suggest that a decreased atrial stretch, due to a reduced venous return, could account for the blunted ANP response to erect posture and exercise in patients with venous valvular incompetency.
R A Mangiafico; L S Malatino; M Santonocito; R S Spada; G Polizzi; B Stancanelli; C Leonardi; G Tamburino
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International angiology : a journal of the International Union of Angiology     Volume:  12     ISSN:  0392-9590     ISO Abbreviation:  Int Angiol     Publication Date:  1993 Mar 
Date Detail:
Created Date:  1993-10-15     Completed Date:  1993-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8402693     Medline TA:  Int Angiol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  29-33     Citation Subset:  IM; S    
Instituto di Clinica Medica L. Condorelli, Università di Catania, Italy.
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MeSH Terms
Aldosterone / blood
Atrial Function / physiology
Atrial Natriuretic Factor / blood,  metabolism*
Exercise / physiology*
Posture / physiology*
Renin / blood
Renin-Angiotensin System / physiology
Venous Insufficiency / physiopathology*
Reg. No./Substance:
52-39-1/Aldosterone; 85637-73-6/Atrial Natriuretic Factor; EC

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