| Atrial natriuretic peptide regulates regional vascular volume and venous tone in humans. | |
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MedLine Citation:
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PMID: 12842844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To date, the contribution of basal atrial natriuretic peptide (ANP) levels to resting vascular function in humans is unknown. In the present study we sought to investigate the role of ANP in regulating regional vascular volume and venous tone in healthy subjects. METHODS AND RESULTS: We used radionuclide plethysmography to examine the effects of ANP and the ANP-receptor antagonist A71915 on forearm vascular volume. Creating pressure/volume relations, we determined changes in vascular volume, compliance, and tone. Performing dose-ranging studies, we additionally assessed the potency and specificity of A71915 in the forearm resistance vasculature. Equilibrium blood pool scintigraphy was then used to assess the effects of systemic administration of A71915 on regional intestinal vascular volume. Infusion of ANP increased forearm vascular volume in a dose-dependent manner (maximum 20%; P<0.001), exerting a maximum venodilating effect at plasma levels similar to that seen in heart failure. A71915 increased venous tone, thereby decreasing vascular volume by 9.6+/-1.1%, P<0.001 (forearm), and 2.6+/-0.5%, P=0.01 (intestinal beds). At an infusion ratio of 50:1, A71915 almost completely abolished the effects of ANP on forearm blood flow. CONCLUSIONS: ANP locally regulates regional vascular volume and tone without affecting compliance. |
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Authors:
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Matthias Schmitt; Andrew J M Broadley; Angus K Nightingale; Nicola Payne; Prasad Gunaruwan; Justin Taylor; Leong Lee; John Cockcroft; Allan D Struthers; Michael P Frenneaux |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2003-07-03 |
Journal Detail:
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Title: Arteriosclerosis, thrombosis, and vascular biology Volume: 23 ISSN: 1524-4636 ISO Abbreviation: Arterioscler. Thromb. Vasc. Biol. Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-10-13 Completed Date: 2004-02-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9505803 Medline TA: Arterioscler Thromb Vasc Biol Country: United States |
Other Details:
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Languages: eng Pagination: 1833-8 Citation Subset: IM |
Affiliation:
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University of Wales College of Medicine, Department of Cardiology, Wales Heart Research Institute, Heath Park, Cardiff CF14 4XN,UK. matthschmitt@doctors.org.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Atrial Natriuretic Factor / blood, pharmacology, physiology* Blood Volume / drug effects, physiology* Compliance / drug effects Dose-Response Relationship, Drug Female Forearm / blood supply* Humans Infusions, Intravenous Male Middle Aged Peptide Fragments / pharmacology Receptors, Atrial Natriuretic Factor / antagonists & inhibitors Regional Blood Flow / drug effects, physiology Tetrahydroisoquinolines / pharmacology Vasodilation / drug effects, physiology* Veins / physiology |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Tetrahydroisoquinolines; 132956-87-7/A 71915; 85637-73-6/Atrial Natriuretic Factor; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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