Document Detail

Atrial natriuretic peptide and nitric oxide in children with pulmonary hypertension after surgical repair of congenital heart disease.
MedLine Citation:
PMID:  8540445     Owner:  NLM     Status:  MEDLINE    
ANP causes pulmonary vasodilation in some children with pulmonary hypertension secondary to congenital heart disease. In a small group of patients, ANP lowered mean pulmonary artery pressure and pulmonary vascular resistance index > 20% without changing systemic vascular resistance index. Inhaled NO is an effective pulmonary vasodilator and is a more selective pulmonary vasodilator than ANP. The utility of ANP may be limited by its nonselective effects as more selective vasodilator agents are available.
D D Ivy; J P Kinsella; R R Wolfe; S H Abman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  77     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1996 Jan 
Date Detail:
Created Date:  1996-02-06     Completed Date:  1996-02-06     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  102-5     Citation Subset:  AIM; IM    
Department of Pediatrics, University of Colorado School of Medicine, Denver, USA.
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MeSH Terms
Analysis of Variance
Atrial Natriuretic Factor / blood*
Child, Preschool
Heart Defects, Congenital / blood*,  complications,  physiopathology,  surgery
Hypertension, Pulmonary / blood*,  etiology,  physiopathology
Nitric Oxide / blood*
Vascular Resistance / physiology
Grant Support
H241012//PHS HHS; H46481//PHS HHS
Reg. No./Substance:
10102-43-9/Nitric Oxide; 85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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