Document Detail


Atrial natriuretic peptide levels in adult patients before and after surgery for correction of atrial septal defects: relationship with atrial arrhythmias.
MedLine Citation:
PMID:  15142035     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the present study, we have examined whether increased N-ANP (N-terminal pro-ANP) levels before and after surgery in patients with ASD (atrial septal defect) along with echocardiographic findings provide a better insight into the pathophysiology and increased morbidity and mortality following corrective surgery. Eighteen adult ASD patients (> 20 years of age; six male and 12 female) with shunts (Qp/Qs > or = 2, where Qp/Qs is the pulmonary blood flow/systemic blood flow) had complete echocardiographic, clinical and laboratory parameters evaluated before and 6 months after surgery. Eight age- and sex-matched individuals (three male and five female) were enrolled as a control group. Blood samples for N-ANP analysis were obtained in both groups. N-ANP levels in the peripheral blood sample from ASD patients before surgery were significantly higher than those in the control group. In patients with ASD, mean N-ANP levels obtained from the pulmonary artery were significantly higher than that obtained from the peripheral vein. RA (right atrial) area, adjusted for body surface area, and RA long-axis and short-axis measurements were significantly higher in the patient group than the control group. N-ANP was correlated significantly with these parameters. Following corrective surgery, N-ANP values and RA area, RA long-axis and short-axis normalization decreased significantly and were accompanied by a decrease in systolic mean pulmonary artery pressure. N-ANP levels were normalized following septal closure in most patients, except in those with atrial fibrillation attacks following corrective surgery. In conclusion, we have shown correlations among variables indicating changes in the architecture of the right atrium along with temporal changes in ANP providing insights into the pathophysiology of post-operative atrial arrhythmias.
Authors:
Ali R Erbay; Mehmet B Yilmaz; Mustafa Balci; Irfan Sabah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  107     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-08-18     Completed Date:  2004-10-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  297-302     Citation Subset:  IM    
Affiliation:
Cardiology Clinic, Yuksek Ihtisas Hospital, Sihhiye, Ankara, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atrial Fibrillation / blood,  etiology*,  ultrasonography
Atrial Natriuretic Factor / blood*
Chi-Square Distribution
Echocardiography
Female
Heart Septal Defects, Atrial / blood,  surgery*,  ultrasonography
Humans
Male
Postoperative Complications / blood,  etiology*,  ultrasonography
Chemical
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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