Document Detail

Atrial natriuretic peptide in congestive heart failure after acute myocardial infarction.
MedLine Citation:
PMID:  8519004     Owner:  NLM     Status:  MEDLINE    
The concentration of atrial natriuretic peptide, a newly discovered hormone produced in the atrial wall, was measured in 55 patients during the first 72 h after acute myocardial infarction. 37 patients became clinically congested, while 18 patients avoided this complication. 13 patients (9 congested and 4 uncongested) experienced tachycardia, known to raise the concentration of atrial natriuretic peptide both with and without congestive heart failure. In the remaining 42 patients, the congested group had a significantly higher plasma atrial natriuretic peptide concentration than the uncongested group (p < 0.05) on all 3 days. In the congested group the concentration of atrial natriuretic peptide did not normalize after initiation of treatment. We conclude that the concentration of atrial natriuretic peptide is increased in all patients with acute myocardial infarction and that the level of atrial natriuretic peptide declines during the first 24 h in all patients and normalizes in the uncongested patients while the level of atrial natriuretic peptide is still elevated (at least for 72 h) in the congested patients.
J Svanegaard; K Angelo-Nielsen; T Pindborg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiology     Volume:  82     ISSN:  0008-6312     ISO Abbreviation:  Cardiology     Publication Date:  1993  
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1266406     Medline TA:  Cardiology     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  1-6     Citation Subset:  IM    
Department of Clinical Chemistry, Svendborg Hospital, Denmark.
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MeSH Terms
Aged, 80 and over
Atrial Natriuretic Factor / blood*
Heart Atria / physiopathology
Heart Failure / physiopathology*
Hemodynamics / physiology*
Middle Aged
Myocardial Infarction / physiopathology*
Pressoreceptors / physiopathology
Reference Values
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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