Document Detail


Atrial natriuretic peptide in the Milan hypertensive rat and the Milan normotensive rat: plasma concentration and binding to renal glomeruli in young, adult and aged rats.
MedLine Citation:
PMID:  7868867     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: Blood pressures were determined in Milan hypertensive (MHS) and Milan normotensive (MNS) rats at different ages. Mean blood pressure, plasma atrial natriuretic peptide (ANP) concentration and renal glomerular receptors numbers and affinities were determined in young (25-day-old), adult (60- to 80-day-old) and aged (300-day-old) rats. RESULTS: Mean blood pressures, always higher in the MHS than in the MNS rats, increased with age in both strains. Plasma ANP concentrations were similar in the young and aged rats of both strains, but were higher in the adult MHS than in the adult MNS rats. There were no quantitative differences in the ANP receptors between young and old rats of the two strains, but an increase in the maximal binding capacity was observed, in both strains, when adult rats were compared with young rats. Moreover, saturation experiments with [125I]-rat ANP revealed a downregulation of the ANP receptors in the renal glomeruli isolated from the adult MHS rats. In isolated glomeruli the cyclic GMP stimulation by ANP was similar in adult rats of both strains. CONCLUSION: Downregulation in glomeruli of MHS rats, probably involving the clearance receptors for ANP, is concluded to occur.
Authors:
H B Aptel; C F Deacon; I W Henderson
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  12     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-03-29     Completed Date:  1995-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1209-15     Citation Subset:  IM    
Affiliation:
Sheffield University, Department of Animal and Plant Sciences, UK.
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MeSH Terms
Descriptor/Qualifier:
Aging / metabolism
Animals
Atrial Natriuretic Factor / blood,  metabolism*
Binding Sites
Blood Pressure
Cyclic GMP / biosynthesis
Disease Models, Animal
Down-Regulation
Hypertension / blood,  metabolism*
Kidney Glomerulus / metabolism*
Male
Radioimmunoassay
Rats
Receptors, Atrial Natriuretic Factor / metabolism
Chemical
Reg. No./Substance:
7665-99-8/Cyclic GMP; 85637-73-6/Atrial Natriuretic Factor; EC 4.6.1.2/Receptors, Atrial Natriuretic Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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