| Atrial natriuretic peptide during different pacing modes in a comparison with hemodynamic changes. | |
| | |
MedLine Citation:
|
PMID: 1692127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The study investigates the response of atrial natriuretic peptide (ANP) to different cardiac pacing modes in comparison with hemodynamic changes. Ten patients underwent Swan-Ganz catheterization during pacemaker implant. Atrioventricular and ventricular pacing were performed consecutively at three pacing rate levels (80, 100, and 110 ppm). Blood samples were taken from the pulmonary artery for ANP determination, both basally and at the end of each pacing period. Concomitantly, mean pulmonary capillary wedge pressure (PCWP) and mean pulmonary artery pressure (PAP) were measured. Cardiac output (CO) was determined by thermodilution both basally and during the 110 ppm steps. During atrioventricular pacing, whereas no significant changes were observed for ANP, PCWP and PAP, CO increased significantly (P less than 0.0005). At the beginning of ventricular pacing hemodynamic parameters and ANP levels were comparable with those of baseline conditions. During subsequent ventricular pacing PCWP and ANP increased significantly at the 110 ppm rate step (P less than 0.05). PAP did not change significantly, whereas CO decreased in all cases (P less than 0.01). A positive correlation was observed between ANP and PCWP during ventricular (P less than 0.001), but not atrioventricular pacing. The results, while confirming the hemodynamic advantages of atrioventricular pacing, point to a major stimulation of ANP secretion during ventricular pacing. This fact, together with the observed drop in CO and the correlation between ANP and PCWP, suggest that the increase of ANP in ventricular pacing may be the expression of a compensatory mechanism to the hemodynamic disadvantages of atrioventricular asynchrony. |
| | |
Authors:
|
M T Baratto; S Berti; A Clerico; E Fommei; M G Del Chicca; C Contini |
Related Documents
:
|
12413257 - Perioperative plasma concentrations of atrial and brain natriuretic peptides in patient... 2966547 - Atrial natriuretic peptide in congestive heart failure: postural changes and reset with... 8914567 - Cardiovascular collapse due to intravenous verapamil in two patients with persistent at... 16216607 - Measurement and reproducibility of magnetocardiographic filtered atrial signal in patie... 7004797 - Combined alpha- and beta-blockade with labetalol in post-open heart surgery hypertensio... 22856287 - Thermal decomposition kinetics of brazilian limestones: effect of co2 partial pressure. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Pacing and clinical electrophysiology : PACE Volume: 13 ISSN: 0147-8389 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 1990 Apr |
Date Detail:
|
Created Date: 1990-06-07 Completed Date: 1990-06-07 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 432-42 Citation Subset: IM |
Affiliation:
|
Institute of Clinical Physiology, National Research Council, Pisa, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Atrial Natriuretic Factor / blood* Atrioventricular Node Blood Pressure / physiology Cardiac Output / physiology Cardiac Pacing, Artificial* / methods Female Heart Block / therapy Heart Rate / physiology Heart Ventricles Hemodynamics / physiology* Humans Male Middle Aged Pulmonary Artery / physiopathology Pulmonary Wedge Pressure / physiology Sick Sinus Syndrome / therapy |
| Chemical | |
Reg. No./Substance:
|
85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The defibrillation success rate versus energy relationship: Part II--Estimation with the "bootstrap"...
Next Document: Mechanism of double ventricular response to a single atrial extrastimulus in patients with Wolff-Par...