Document Detail

Atrial natriuretic peptide and bronchial hyperresponsiveness in patients with mitral stenosis.
MedLine Citation:
PMID:  8341858     Owner:  NLM     Status:  MEDLINE    
Atrial natriuretic peptide (ANP) has been reported to have protective effects against methacholine-induced bronchoconstriction in asthmatics. The aim of the study was to evaluate the relationship between plasma ANP levels and bronchial responsiveness to methacholine in patients with mitral stenosis. In 12 patients with moderate mitral stenosis, age 35-58 years, 9 female, 8 in NYHA class 2, 4 in NYHA class 3 for symptoms, plasma ANP and bronchial threshold to methacholine (PD20FEV1) were determined. The same measurements were performed in 10 asthmatic patients, hyperresponsive to methacholine, and in 10 normal subjects, nonresponsive to methacholine. Mean +/- SE plasma ANP levels were significantly higher in patients with mitral stenosis in comparison with asthmatics and normals (159 +/- 41.8, 7.3 +/- 0.98, 7.6 +/- 1.3, respectively, p < 0.01). In patients with mitral stenosis there was a significant relationship between plasma ANP and PD20FEV1 (r = 0.81, p < 0.01). No relationship was found between ANP and PD20FEV1 in asthmatics. In conclusion, in patients with mitral stenosis ANP seems to play a protective role against bronchial hyperresponsiveness to methacholine.
G Rolla; C Bucca; L Brussino; S Bergerone; F Pecchio
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Respiration; international review of thoracic diseases     Volume:  60     ISSN:  0025-7931     ISO Abbreviation:  Respiration     Publication Date:  1993  
Date Detail:
Created Date:  1993-09-02     Completed Date:  1993-09-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0137356     Medline TA:  Respiration     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  74-7     Citation Subset:  IM    
Department of Biomedical Science, University of Torino, Italy.
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MeSH Terms
Asthma / physiopathology
Atrial Natriuretic Factor / blood*,  physiology
Bronchial Hyperreactivity / physiopathology*
Bronchial Provocation Tests
Methacholine Chloride / diagnostic use
Middle Aged
Mitral Valve Stenosis / physiopathology*
Reg. No./Substance:
62-51-1/Methacholine Chloride; 85637-73-6/Atrial Natriuretic Factor

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