| Atrial natriuretic peptide and brain natriuretic peptide release in human essential hypertension. | |
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MedLine Citation:
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PMID: 19462934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Hypertension is associated with an increase in vasoactive peptides, but conflicting results are reported concerning their causes of elevation. In this study, cardiac vasodilator hormones atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), and vasoconstrictor hormones (renin, aldosterone, cortisol, metanephrins) were determined in 36 hypertensive subjects (HT) without left ventricular hypertrophy (LVH), 19 healthy subjects without family hypertension (NTFN) and 35 healthy subjects with family hypertension (NTFH). Plasma levels of ANP and BNP were significantly higher (p<0.04) in HT subjects (28.1 +/- 6.1 and 22.7 +/- 6.8 pg/ml) compared to NTFN (13.4 +/- 3.3 and 6.1 +/- 1.5 pg/ml) and NTFH (12.5 +/- 1.4 and 7.2 +/- 1.3 pg/ml) subjects, respectively. No significant differences were observed in ANP and BNP concentrations between NTFN and NTFH. Measurement of vasoconstrictor hormones showed no significant differences between the three groups. Plasma ANP and BNP concentrations were significantly correlated in both HT (r=0.73; P<0.001), NTFN (r=0.71; P<0.002) and NTFH (r=0.53; P<0.003) subjects. ANP values were significantly related to systolic blood pressure (r=0.34; P<0.05) in the HT group while BNP values were not. The echocardiographic findings were not correlated with ANP or BNP in the HT patients. This suggests that natriuretic peptides increase is related to the blood pressure elevation rather than LVH to reduce detrimental high BP effects. |
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Authors:
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Hayet Soualmia; Ilhem Ayadi; Souheil Omar; Moncef Feki; Habiba Drissa; Abderraouf Mebazaa; Naziha Kaabachi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Clinical laboratory Volume: 55 ISSN: 1433-6510 ISO Abbreviation: Clin. Lab. Publication Date: 2009 |
Date Detail:
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Created Date: 2009-05-25 Completed Date: 2009-06-18 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9705611 Medline TA: Clin Lab Country: Germany |
Other Details:
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Languages: eng Pagination: 120-7 Citation Subset: IM |
Affiliation:
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LR99ES11 Research Laboratory and Department of Biochemistry, Rabta Hospital, Tunis, Tunisia. hayetsoualmia@yahoo.fr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Atrial Natriuretic Factor / blood* Blood Pressure Electrocardiography Humans Hypertension / blood* Hypertrophy, Left Ventricular / blood Middle Aged Natriuretic Peptide, Brain / blood* Vasoconstriction Vasodilation |
| Chemical | |
Reg. No./Substance:
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114471-18-0/Natriuretic Peptide, Brain; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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