Document Detail

Atrial natriuretic hormone inhibits angiotensin II-stimulated sympathetic nerve activity in humans.
MedLine Citation:
PMID:  8770149     Owner:  NLM     Status:  MEDLINE    
We examined the effect of intravenous infusion of atrial natriuretic hormone (ANH) on the response of muscle sympathetic nerve activity (MSNA) to infused angiotensin II (ANG II) in humans. Infusion of saline alone or ANH (10 alone produced no significant change in MSNA, whereas the infusion of ANG II (5 alone caused a decrease in MSNA. Because elevations in arterial pressure (AP) and central venous pressure (CVP) also occurred due to ANG II, such elevations in AP and CVP could inhibit MSNA via baroreflexes. Then, the effect of ANG II on AP and CVP was inhibited by the simultaneous infusion of nitroprusside (N). Infusion of ANG II (5 produced significant increases in MSNA when ANG II was infused along with N. However, the simultaneously infused ANH (10 abolished the increases in MSNA induced by ANG II when the elevation in AP and CVP was inhibited by N. Thus ANH inhibits ANG II-induced sympathetic activation in humans. The results suggest that ANH may modulate sympathetic nerve activity at least in part by antagonizing the action of ANG II.
T Matsukawa; T Mano
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  271     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1996 Aug 
Date Detail:
Created Date:  1996-10-30     Completed Date:  1996-10-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R464-71     Citation Subset:  IM    
Department of Autonomic and Behavioral Neurosciences, Nagoya University, Japan.
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MeSH Terms
Angiotensin II / antagonists & inhibitors,  pharmacology*
Atrial Natriuretic Factor / pharmacology*
Blood Pressure / drug effects
Central Venous Pressure / drug effects
Drug Interactions
Heart Rate / drug effects
Middle Aged
Muscles / innervation
Nitroprusside / pharmacology
Norepinephrine / blood
Sympathetic Nervous System / drug effects*,  physiology
Reg. No./Substance:
11128-99-7/Angiotensin II; 15078-28-1/Nitroprusside; 51-41-2/Norepinephrine; 85637-73-6/Atrial Natriuretic Factor

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