Document Detail

Atrial natriuretic factor inhibits mitogen-induced growth in aortic smooth muscle cells.
MedLine Citation:
PMID:  12209885     Owner:  NLM     Status:  MEDLINE    
Atrial natriuretic factor (ANF) is a polypeptide able to affect cardiovascular homeostasis exhibiting diuretic, natriuretic, and vasorelaxant activities. ANF shows antimitogenic effects in different cell types acting through R(2) receptor. Excessive proliferation of smooth muscle cells is a common phenomenon in diseases such as atherosclerosis, but the role of growth factors in the mechanism which modulate this process has yet to be clarified. The potential antimitogenic role of ANF on the cell growth induced by growth factors appears very intriguing. Aim of the present study was to investigate the possible involvement of ANF on rat aortic smooth muscle (RASM) cells proliferation induced by known mitogens and the mechanism involved. Our data show that ANF, at physiological concentration range, inhibits RASM cell proliferation induced by known mitogens such as PDGF and insulin, and the effect seems to be elicited through the modulation of phosphatidic acid (PA) production and MAP kinases involvement.
P M Baldini; P De Vito; M Fraziano; P Mattioli; P Luly; P Di Nardo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  193     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-04     Completed Date:  2002-09-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  103-9     Citation Subset:  IM    
Copyright Information:
Copyright 2002 Wiley-Liss, Inc.
Department of Biology, University of Rome Tor Vergata, Rome, Italy.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Aorta / cytology,  drug effects*,  metabolism
Atenolol / pharmacology
Atrial Natriuretic Factor / pharmacology*
Cell Cycle / drug effects
Cell Division / drug effects
Cells, Cultured
DNA / biosynthesis
Flow Cytometry
Insulin / pharmacology
Mitogens / pharmacology*
Muscle, Smooth, Vascular / cytology,  drug effects*,  metabolism
Phosphatidic Acids / metabolism
Platelet-Derived Growth Factor / pharmacology
Rats, Wistar
Signal Transduction / drug effects,  physiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Mitogens; 0/Phosphatidic Acids; 0/Platelet-Derived Growth Factor; 11061-68-0/Insulin; 29122-68-7/Atenolol; 85637-73-6/Atrial Natriuretic Factor; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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