Document Detail

Atrial natriuretic factor in the acute nephritic and nephrotic syndromes.
MedLine Citation:
PMID:  2146429     Owner:  NLM     Status:  MEDLINE    
Because the role of systemic hormones in the pathophysiology of edema in acute renal disease remains incompletely understood, we compared the levels of atrial natriuretic factor (ANF) and plasma renin activity (PRA) in patients with acute glomerulonephritis (AGN), nephrotic syndrome (NS), and normal individuals during salt deprivation and salt loading. Sixteen patients with AGN (10 males) and nine patients with NS and hypoalbuminemia (7 males) were studied on admission, and after recovery (12 AGN patients) or remission (4 NS patients). Eighteen normal controls were each studied after five days on a low (20 mEq Na/day), regular (120 mEq Na/day) and high (300 mEq Na/day) dietary salt intake. Patients with AGN and NS had comparable edema (AGN 2.8 +/- 0.53 kg; NS 3.36 +/- 0.47 kg; SE) and urinary Na excretion (mean +/- SEM: AGN 0.97 +/- 0.11 mEq/hr; NS 1.06 +/- 0.16 mEq/hr), but AGN patients had five times higher ANF (AGN 27.2 +/- 4.06 fmol/ml; NS 5.51 +/- 1.02 fmol/ml; P less than 0.001) and six times lower PRA ng/liter.sec levels (AGN 0.187 +/- 0.047; NS 1.144 +/- 0.222; P less than 0.001) than NS patients. The degree of edema was correlated with ANF levels in AGN patients (P less than 0.001) but not in NS patients. There was a strong exponential negative correlation (r = -0.773, P less than 0.0001) between ANF and PRA, in which AGN patients and Na-restricted controls were located in the opposite ends of the volume sensing-response, and NS patients in the middle, alongside controls with regular Na intake.(ABSTRACT TRUNCATED AT 250 WORDS)
B Rodríguez-Iturbe; D Colic; G Parra; J Gutkowska
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Kidney international     Volume:  38     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  1990 Sep 
Date Detail:
Created Date:  1990-12-13     Completed Date:  1990-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  512-7     Citation Subset:  IM    
Renal Service and Laboratory, Hospital Universitario, Maracaibo, Venezuela.
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MeSH Terms
Acute Disease
Atrial Natriuretic Factor / blood*
Diet, Sodium-Restricted
Edema / physiopathology
Glomerulonephritis / blood*,  physiopathology
Natriuresis / physiology
Nephrotic Syndrome / blood*,  physiopathology
Renin / blood
Sodium, Dietary / administration & dosage
Reg. No./Substance:
0/Sodium, Dietary; 85637-73-6/Atrial Natriuretic Factor; EC

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