Document Detail

Atrial natriuretic factor: implications in congestive heart failure and hypertension.
MedLine Citation:
PMID:  2528638     Owner:  NLM     Status:  MEDLINE    
The physiological actions of the atrial peptide system are discussed in relation to its potential role in the aetiology and treatment of hypertension and congestive heart failure (CHF). Atrial natriuretic factor (ANF) exerts marked natriuretic, diuretic and vasodilatory effects and has been demonstrated to reduce blood pressure by several mechanisms, actions which serve to protect the central circulation against volume and pressure overload. It was initially believed that CHF may relate to a deficiency of ANF, but studies of experimentally induced and human CHF have shown elevated levels of circulating ANF, reflecting a compensatory increase in response to reduced cardiac output. In contrast, plasma levels of ANF in hypertension not complicated by CHF are normal and it might be speculated that hypertension reflects an attenuated ANF response to increase cardiac volume and/or pressure. ANF may play an important role in these cardiovascular disease states and, with the availability of synthetic ANF analogues, may also have therapeutic potential.
J C Burnett
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of human hypertension     Volume:  3 Suppl 1     ISSN:  0950-9240     ISO Abbreviation:  J Hum Hypertens     Publication Date:  1989 Jun 
Date Detail:
Created Date:  1989-10-20     Completed Date:  1989-10-20     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8811625     Medline TA:  J Hum Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  41-6     Citation Subset:  IM    
Department of Internal Medicine and Physiology, Mayo Clinic, Rochester, Minnesota 55905.
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MeSH Terms
Atrial Natriuretic Factor / metabolism,  physiology*
Heart Failure / metabolism,  physiopathology*
Hypertension / metabolism,  physiopathology*
Reg. No./Substance:
85637-73-6/Atrial Natriuretic Factor

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