Document Detail

Atrial natriuretic factor immunoreactivity in human fetal lung tissue and perfusates.
MedLine Citation:
PMID:  2964406     Owner:  NLM     Status:  MEDLINE    
Immunoreactive atrial natriuretic factor (ANF) was detected in human fetal homogenates and perfusates using a sensitive and specific radioimmunoassay for the 28 amino acid (C-terminal) fragment. Three peaks of ANF immunoreactive material were found in the lung homogenates. With high performance liquid chromatography, the elution characteristics of the first immunoreactive peak were the same as those of circulating human ANF. The other two peaks have not been characterized, although one had a position similar to the 126 amino acid rat prohormone (Asn 1-Ile 110-Tyr 126). The time course of release of immunoreactive ANF by perfused human fetal lungs was also studied. It is suggested that ANF may play a role in early pulmonary function.
P Sirois; J Gutkowska
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Hypertension     Volume:  11     ISSN:  0194-911X     ISO Abbreviation:  Hypertension     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1988-04-11     Completed Date:  1988-04-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7906255     Medline TA:  Hypertension     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  I62-5     Citation Subset:  IM    
Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada.
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MeSH Terms
Atrial Natriuretic Factor / analysis*,  physiology
Chromatography, High Pressure Liquid
Fetus / metabolism
Lung / analysis*
Reg. No./Substance:
0/NPPA protein, human; 85637-73-6/Atrial Natriuretic Factor

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