| Atrial natriuretic factor immunoreactivity in human fetal lung tissue and perfusates. | |
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MedLine Citation:
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PMID: 2964406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Immunoreactive atrial natriuretic factor (ANF) was detected in human fetal homogenates and perfusates using a sensitive and specific radioimmunoassay for the 28 amino acid (C-terminal) fragment. Three peaks of ANF immunoreactive material were found in the lung homogenates. With high performance liquid chromatography, the elution characteristics of the first immunoreactive peak were the same as those of circulating human ANF. The other two peaks have not been characterized, although one had a position similar to the 126 amino acid rat prohormone (Asn 1-Ile 110-Tyr 126). The time course of release of immunoreactive ANF by perfused human fetal lungs was also studied. It is suggested that ANF may play a role in early pulmonary function. |
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Authors:
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P Sirois; J Gutkowska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Hypertension Volume: 11 ISSN: 0194-911X ISO Abbreviation: Hypertension Publication Date: 1988 Feb |
Date Detail:
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Created Date: 1988-04-11 Completed Date: 1988-04-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7906255 Medline TA: Hypertension Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: I62-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Faculty of Medicine, University of Sherbrooke, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Natriuretic Factor
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analysis*,
physiology Chromatography, High Pressure Liquid Fetus / metabolism Humans Lung / analysis* Radioimmunoassay |
| Chemical | |
Reg. No./Substance:
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0/NPPA protein, human; 85637-73-6/Atrial Natriuretic Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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