| Atrial natriuretic factor, but not oxytocin, is present in atherosclerotic plaques of human common carotid arteries. | |
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MedLine Citation:
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PMID: 20198825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed a study on 25 common carotid arteries (CCA) affected by atherosclerotic plaques, comparing them to 25 normal CCA. We researched the presence and localisation of atrial natriuretic factor (ANF) and oxytocin (OX) by immunohistochemistry. We found ANF abundantly expressed in plaques, mainly localising in intima and subintima layers; by contrast normal vessels were scarcely positive or negative; finally, OX resulted negative or weakly positive in both atherosclerotic and normal vessels. Our results show for the first time ANF presence in atherosclerotic plaques of CCA and are in agreement with other studies, mainly performed in vitro, that hypothesise the involvement of this molecule in the modulation of atherosclerotic inflammatory lesions and its use as anti-inflammatory agent. |
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Authors:
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Gaetano La Barbera; Giuseppe La Marca; Fabrizio Valentino; Diego Lipari; Giovanni Peri; Francesco Cappello; Biagio Valentino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia Volume: 114 ISSN: 1122-6714 ISO Abbreviation: Ital J Anat Embryol Publication Date: 2009 Apr-Sep |
Date Detail:
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Created Date: 2010-03-04 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9612303 Medline TA: Ital J Anat Embryol Country: Italy |
Other Details:
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Languages: eng Pagination: 129-36 Citation Subset: IM |
Affiliation:
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Unit? Operativa Complessa di Chirurgia Vascolare, ARNAS "Civico e Benfratelli", Palermo, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Anti-Inflammatory Agents / pharmacology Atrial Natriuretic Factor / analysis, metabolism* Biological Markers Carotid Artery Diseases / metabolism*, pathology, physiopathology Carotid Stenosis / metabolism*, pathology, physiopathology Drug Design Female Humans Immunohistochemistry Male Middle Aged Oxytocin / analysis, metabolism* Tunica Intima / metabolism, pathology Vasculitis, Central Nervous System / metabolism, pathology, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents; 0/Biological Markers; 50-56-6/Oxytocin; 85637-73-6/Atrial Natriuretic Factor |
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