Document Detail

Atrial natriuresis under the condition of a constant renal perfusion pressure: experiments on conscious dogs.
MedLine Citation:
PMID:  7193469     Owner:  NLM     Status:  MEDLINE    
An experimental elevation of left atrial pressure (eLAP) by means of a reversible mitral stenosis is accompanied with an increase in sodium excretion (UNaV) and arterial blood pressure (by about 20 mm Hg, 2.7 kPa), and by a decrease in plasma renin activity. It is well established that an increase in renal perfusion pressure (Pren) can augment UNaV. Therefore the present study was undertaken to examine whether the eLAP-induced natriuresis was caused by the increased Pren. -Four female beagle dogs were kept under controlled environmental conditions. They received a sodium rich diet (14.5 mmol/Na/kg/d). The dogs were chronically instrumented: purse string around the mitral annulus, catheter in the left atrium, carotid loop, pneumatic cuff above the renal arteries, pressure transducer below the renal arteries. Pren was kept constant by means of a digital servofeedback control circuit. The dogs served as their own controls (13 experiments without and 15 experiments with a controlled renal perfusion pressure were performed). After eLAP(+1.0 kPa), UNaV rose from 4.1 +/- 2.6 to 10.3 +/- 3.9 mumol Na/min/kg. If Pren was kept constant, the corresponding values were 4.2 +/- 2.8 and 9.3 +/- 2.9 mumol/min/kg. These data clearly indicate that the atrial natriuresis is not mediated by an augmentation of renal perfusion pressure. Therefore these results support the hypothesis that atrial natriuresis probably is due to en eLAP-induced suppression of the renin-angiotensin-system or other natriuretic mechanisms.
H W Reinhardt; G Kaczmarczyk; R Mohnhaupt; B Simgen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pflügers Archiv : European journal of physiology     Volume:  389     ISSN:  0031-6768     ISO Abbreviation:  Pflugers Arch.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-05-28     Completed Date:  1981-05-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0154720     Medline TA:  Pflugers Arch     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  9-15     Citation Subset:  IM    
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MeSH Terms
Atrial Function
Blood Pressure*
Chlorides / urine
Heart / physiology*
Kidney / physiology
Potassium / urine
Sodium / urine
Reg. No./Substance:
0/Chlorides; 7440-09-7/Potassium; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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