Document Detail

Atrial flutter with 1:1 atrioventricular conduction caused by propafenone.
MedLine Citation:
PMID:  9793099     Owner:  NLM     Status:  MEDLINE    
We describe a case of 1:1 atrial flutter in a patient with coronary disease taking propafenone. In atrial flutter, the atrial rate is usually about 300 beats/min with 2:1 AV conduction and a ventricular rate of 150 beats/min. Class IA antiarrhythmic drugs, especially quinidine and disopyramide, may cause 1:1 AV response because they reduce atrial rate and are vagolytic. However, propafenone is a Class IC agent and has no anticholinergic properties, and the occurrence of 1:1 AV conduction at a rate of about 250 beats/min is an important side effect that, although uncommon, should be recognized.
M B el-Harari; P C Adams
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  21     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-21     Completed Date:  1998-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1999-2001     Citation Subset:  IM    
Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom.
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MeSH Terms
Anti-Arrhythmia Agents / adverse effects*,  therapeutic use
Atrial Fibrillation / drug therapy
Atrial Flutter / chemically induced*
Atrioventricular Node / drug effects*
Coronary Artery Bypass
Heart Rate / drug effects
Middle Aged
Postoperative Complications / drug therapy
Propafenone / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 54063-53-5/Propafenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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