Document Detail

Atrial fibrillation may be a vascular disease: the role of the pulmonary vein.
MedLine Citation:
PMID:  17011134     Owner:  NLM     Status:  MEDLINE    
Recent years have seen an enormous amount of experimental and clinical research into role of the pulmonary veins (PVs) in atrial fibrillation (AF). The PVs contain cardiomyocytes with easily inducible arrhythmogenic activity due to the enhanced automaticity, induction of triggered activity, and genesis of microreentrant circuits. The enhanced automaticity, induced triggered activity, either alone or in combination with the reentrant mechanisms, may play a role in the initiation of PVs AF. Detailed mapping studies suggest that reentry within the PVs is most likely responsible for their arrhythmogenicity. There is no doubt that the PVs represent the most important source of arrhythmogenic activity in patients with paroxysmal AF. In AF patients with risk factors for development of AF, the presence of the pathological situation is important in enhancing the PV arrhythmogenic activity. Coronary sinus or superior vena cava may also be a source of rapid repetitive electrical activity during AF. Thus, AF should be considered a kind of vascular disease. Moreover, in patients with paroxysmal AF originating from the PVs, a wide spectrum of atrial arrhythmias may coexist, including paroxysms of atrial premature, tachycardia, flutter and fibrillation. This kind of arrhythmias should be named as PV atrial arrhythmias. These new views will help understand the mechanism, diagnosis and treatment method for AF.
Cong Xin Huang; Cheng Lin Hu; Yan Bo Li
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Publication Detail:
Type:  Journal Article     Date:  2006-09-29
Journal Detail:
Title:  Medical hypotheses     Volume:  68     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  2007  
Date Detail:
Created Date:  2007-01-08     Completed Date:  2007-04-05     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  629-34     Citation Subset:  IM    
Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan 430060, PR China.
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MeSH Terms
Atrial Fibrillation / physiopathology*
Pulmonary Veins / physiopathology*
Vascular Diseases / physiopathology*

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