Document Detail

Atrial fibrillation-induced endothelial dysfunction improves after restoration of sinus rhythm.
MedLine Citation:
PMID:  23269316     Owner:  NLM     Status:  Publisher    
BACKGROUND: Recent evidence suggests that atrial fibrillation (AF) adversely affects endothelial function. The goal of this study was to assess endothelial function in patients with AF before and after restoration of sinus rhythm by catheter ablation (ABL). METHODS: Reactive hyperemia peripheral arterial tonometry (RH-PAT) measurements reflecting endothelial function were conducted with Endo-PAT2000 (Itamar Medical, Caesarea, Israel) in 27 patients with persistent AF before ABL and in 21 control subjects with sinus rhythm (SR). According to cardiac rhythm on the morning after ABL, patients were divided into two groups: day 1-restored SR group (n=19) and day 1-recurred AF group (n=8). Based on the cardiac rhythm at 6months after ABL, the restored SR group was further subdivided into the month 6-maintained SR group (n=11) and the month 6-recurred AF group (n=6). RESULTS: Log(e) RH-PAT index (RHI) was significantly lower in the persistent AF group than in the control (SR) group (0.52±0.20; 0.69±0.24, p<0.01). Multivariate logistic regression analysis revealed that persistent AF was the only independent predictor of impaired endothelial function defined as log(e) RHI<0.6 (odds ratio, 4.96; 95% CI, 1.2 to 21.3; p<0.05). Log(e) RHI was significantly higher after ABL than before ABL (0.53±0.20; 0.73±0.25; p<0.01) in the day 1-restored SR group. Log(e) RHI of the month 6-maintained SR group was comparable to that of the day 1-restored SR group. CONCLUSIONS: These results suggest that AF is associated with impairment of endothelial dysfunction and that this impairment is reversed by restoration of sinus rhythm.
Satoshi Yoshino; Akiko Yoshikawa; Shuichi Hamasaki; Sanemasa Ishida; Naoya Oketani; Keishi Saihara; Hideki Okui; So Kuwahata; Shoji Fujita; Hitoshi Ichiki; Nami Ueya; Yasuhisa Iriki; Ryuichi Maenosono; Masaaki Miyata; Chuwa Tei
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-23
Journal Detail:
Title:  International journal of cardiology     Volume:  -     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.
Department of Cardiovascular, Respiratory and Metabolic Medicine, Graduate School of Medicine, Kagoshima University, Kagoshima, Japan.
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