| Atrial fibrillation induced by gemcitabine treatment in a 65-year-old man. | |
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MedLine Citation:
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PMID: 17460420 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Gemcitabine, a pyrimidine analogue, is a cell cycle-specific antineoplastic agent that is structurally related to cytarabine. Major side effects of the treatment with gemcitabine are hepatic dysfunction, myelosuppression, renal impairment and pulmonary toxicity. Development of atrial fibrillation (AF) during gemcitabine treatment is very rare and was reported in only 2 case reports in the literature. CASE REPORT: We report the case of a 65-year-old man who developed AF under gemcitabine therapy for non-small cell lung cancer (stage IIIB). In this patient, AF was intrinsically associated with chemotherapy administration which triggered arrhythmia. CONCLUSION: Although AF caused by gemcitabine appears to be rare, patients at risk of developing atrial fibrillation should be closely monitored for this complication. |
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Authors:
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Yusuf Tavil; Ugur Arslan; Kaan Okyay; Nihat Sen; Bülent Boyaci |
Publication Detail:
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Type: Case Reports; Journal Article Date: 2007-04-24 |
Journal Detail:
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Title: Onkologie Volume: 30 ISSN: 0378-584X ISO Abbreviation: Onkologie Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-26 Completed Date: 2007-07-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7808556 Medline TA: Onkologie Country: Switzerland |
Other Details:
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Languages: eng Pagination: 253-5 Citation Subset: IM |
Affiliation:
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Gazi University Medical School, Department of Cardiology, Ankara, Turkey. yusuftavil@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antimetabolites, Antineoplastic / administration & dosage, adverse effects* Antineoplastic Combined Chemotherapy Protocols / adverse effects*, therapeutic use Atrial Fibrillation / chemically induced*, diagnosis Carcinoma, Non-Small-Cell Lung / drug therapy*, pathology Cisplatin / administration & dosage, adverse effects Deoxycytidine / adverse effects, analogs & derivatives*, therapeutic use Electrocardiography / drug effects Humans Infusions, Intravenous Lung Neoplasms / drug therapy*, pathology Male Neoplasm Staging Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites, Antineoplastic; 103882-84-4/gemcitabine; 15663-27-1/Cisplatin; 951-77-9/Deoxycytidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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