| Atrial fibrillation in primary aldosteronism. | |
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MedLine Citation:
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PMID: 19617274 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Primary aldosteronism (PA) is caused by autonomous hypersecretion of aldosterone from the adrenal cortex, classically from an adenoma, resulting in sodium and water retention, hypokalaemia and raised blood pressure. The sodium and water retention causes suppression of renin release. The possible cardiac sequelae of aldosterone excess are encountered primarily in patients with secondary hyperaldosteronism due to heart failure, where plasma renin, angiotensin and aldosterone levels are all raised. However, there is also evidence that primary aldosterone excess, in the presence of low renin levels, may also be cardiotoxic. PATIENTS: In this report, we describe five patients with PA, who developed atrial fibrillation (AF) in the absence of structural cardiac lesions and in one case despite good control of blood pressure and electrolytes. CONCLUSION: In patients with hypertension and AF, who have no evidence of coronary disease or any other underlying cause of AF with preserved systolic function, a diagnosis of PA should be considered. |
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Authors:
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Timothy Watson; Vellore J Karthikeyan; Gregory Y H Lip; D Gareth Beevers |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2009-07-17 |
Journal Detail:
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Title: Journal of the renin-angiotensin-aldosterone system : JRAAS Volume: 10 ISSN: 1752-8976 ISO Abbreviation: J Renin Angiotensin Aldosterone Syst Publication Date: 2009 Dec |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-02-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100971636 Medline TA: J Renin Angiotensin Aldosterone Syst Country: England |
Other Details:
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Languages: eng Pagination: 190-4 Citation Subset: IM |
Affiliation:
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Department of Medicine, City Hospital, Birmingham B18 7QH, England, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aldosterone / blood Atrial Fibrillation / diagnosis, etiology* Female Humans Hyperaldosteronism / complications*, diagnosis Hypertension / diagnosis, etiology* Hypertrophy, Left Ventricular / diagnosis, etiology Hypokalemia / complications Male Middle Aged Renin / blood |
| Chemical | |
Reg. No./Substance:
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52-39-1/Aldosterone; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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