Document Detail

Atrial fibrillation in heart failure: a comprehensive review.
MedLine Citation:
PMID:  20193823     Owner:  NLM     Status:  MEDLINE    
Chronic heart failure and atrial fibrillation are 2 major disorders that are closely linked. Their coexistence is associated with adverse prognosis. Both share several common predisposing conditions, but their interaction involves complex ultrastructural, electrophysiologic, and neurohormonal processes that go beyond mere sharing of mutual risk factors. Rate control approach remains the standard therapy for atrial fibrillation in heart failure because current strategies at rhythm control have so far failed to positively impact mortality and morbidity. This is largely because of the shortcomings of current pharmacologic anti-arrhythmic agents. Surgical and catheter-based therapies are promising, but long-term data are lacking. The role of non-anti-arrhythmic therapeutic agents also is being explored. Further progress toward improved understanding the complex relationship between atrial fibrillation and heart failure should improve management strategies.
Prakash C Deedwania; Joel A Lardizabal
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of medicine     Volume:  123     ISSN:  1555-7162     ISO Abbreviation:  Am. J. Med.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-02     Completed Date:  2010-04-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  198-204     Citation Subset:  AIM; IM    
Copyright Information:
Published by Elsevier Inc.
Department of Medicine, University of California, San Francisco, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use
Atrial Fibrillation* / complications,  diagnosis,  therapy
Catheter Ablation / methods
Electrophysiologic Techniques, Cardiac / methods
Heart Failure* / complications,  diagnosis,  therapy
Reg. No./Substance:
0/Anti-Arrhythmia Agents

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