Document Detail

Atrial fibrillation impairs endothelial function of forearm vessels in humans.
MedLine Citation:
PMID:  11264550     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although there have been many studies on the effects of atrial fibrillation (AF) on cardiac function, few studies have been done on its effects on endothelial function. The present study was designed to examine the effects of AF on endothelial function in human subjects. METHODS AND RESULTS: Changes in forearm blood flow (FBF) induced by acetylcholine and nitroglycerin were measured by using plethysmography in 14 patients with lone AF, 13 patients with AF and underlying heart disease, and 12 normal control subjects. In the patients, these measurements were repeated after cardioversion. Although baseline FBF was the same in the 3 groups, acetylcholine-induced increases in FBF were significantly smaller in both patient groups than in the control group, and FBF increases were particularly depressed in AF patients with underlying heart disease. After restoration of sinus rhythm by cardioversion, FBF response to the highest dose of acetylcholine increased by 46% in patients with lone AF (n = 10) and by 90% in AF patients with underlying heart disease (n = 11). Nitroglycerin-induced vasodilatation was the same in all 3 groups and was not affected by cardioversion. CONCLUSIONS: These findings suggest that endothelium-dependent vasodilatation is impaired by AF and improves after sinus rhythm is restored.
N Takahashi; Y Ishibashi; T Shimada; T Sakane; S Ohata; T Sugamori; Y Ohta; S Inoue ; K Nakamura; H Shimizu; H Katoh; K Sano; Y Murakami; M Hashimoto
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiac failure     Volume:  7     ISSN:  1071-9164     ISO Abbreviation:  J. Card. Fail.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-26     Completed Date:  2001-05-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9442138     Medline TA:  J Card Fail     Country:  United States    
Other Details:
Languages:  eng     Pagination:  45-54     Citation Subset:  IM    
Fourth Department of Internal Medicine, Shimane Medical University, Izumo City, Shimane, Japan.
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MeSH Terms
Acetylcholine / administration & dosage
Atrial Fibrillation / physiopathology*
Electric Countershock
Endothelium, Vascular / drug effects,  physiopathology*
Forearm / blood supply*
Middle Aged
Nitroglycerin / administration & dosage
Regional Blood Flow / drug effects,  physiology
Treatment Outcome
Vascular Resistance / drug effects,  physiology
Vasodilation / drug effects,  physiology
Reg. No./Substance:
51-84-3/Acetylcholine; 55-63-0/Nitroglycerin

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