Document Detail

"Atrial fibrillation & hyperthyroidism: relation between transesophageal markers of a thrombogenic milieu and clinical risk factors for thromboembolism"
MedLine Citation:
PMID:  21950838     Owner:  NLM     Status:  Publisher    
Hyperthyroidism is a questionable risk factor for thromboembolism among atrial fibrillation patients. Objective:  To correlate clinical risk factors for thromboembolism from a group of patients with atrial fibrillation related to hyperthyroidism with transesophageal echocardiography (TEE) markers of a thrombogenic milieu. Design:  Clinical risk factors for thromboembolism, thyroid hormonal status, time since diagnosis of hyperthyroidism and TEE markers of a thrombogenic milieu were assessed in consecutive patients with atrial fibrillation related to hyperthyroidism. The following TEE parameters were assessed to define the presence of thrombogenic milieu: dense spontaneous echo contrast, thrombi, or left atrial appendage blood flow velocities <0.20m/s. Clinical risk factors for thromboembolism were based on CHADS(2) (Cardiac failure, Hypertension, Age, Diabetes and Stroke) classification. Patients:  31 consecutive patients aged between 18-65 years old, with atrial fibrillation related to hyperthyroidism scheduled for TEE. Results:  Thrombogenic milieu was present in 14/31 (45.2%) patients. The thyroid status could not predict the presence of a thrombogenic milieu. Despite low CHADS(2) score of 0/1, 6/13 (46.1%) of these patients had a thrombogenic milieu whereas 10/18 (55.6%) patients with score ≥2 had none. The probability of having a thrombogenic milieu did not correlate with the number of clinical risk factors. Conclusion:  Among patients younger than 65 years old with atrial fibrillation related to hyperthyroidism, there is no association between clinical risk factors with TEE markers of a thrombogenic milieu. Transesophageal echocardiography adds useful information which may affect antithrombotic therapy guided by clinical risk classification.
Marcus Vinicius Leitão de Souza; Martha Maria Turano Duarte; Claudia Medina Coeli; Mario Vaisman
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-26
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Blackwell Publishing Ltd.
Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
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