| "Atrial fibrillation & hyperthyroidism: relation between transesophageal markers of a thrombogenic milieu and clinical risk factors for thromboembolism" | |
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MedLine Citation:
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PMID: 21950838 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Hyperthyroidism is a questionable risk factor for thromboembolism among atrial fibrillation patients. Objective: To correlate clinical risk factors for thromboembolism from a group of patients with atrial fibrillation related to hyperthyroidism with transesophageal echocardiography (TEE) markers of a thrombogenic milieu. Design: Clinical risk factors for thromboembolism, thyroid hormonal status, time since diagnosis of hyperthyroidism and TEE markers of a thrombogenic milieu were assessed in consecutive patients with atrial fibrillation related to hyperthyroidism. The following TEE parameters were assessed to define the presence of thrombogenic milieu: dense spontaneous echo contrast, thrombi, or left atrial appendage blood flow velocities <0.20m/s. Clinical risk factors for thromboembolism were based on CHADS(2) (Cardiac failure, Hypertension, Age, Diabetes and Stroke) classification. Patients: 31 consecutive patients aged between 18-65 years old, with atrial fibrillation related to hyperthyroidism scheduled for TEE. Results: Thrombogenic milieu was present in 14/31 (45.2%) patients. The thyroid status could not predict the presence of a thrombogenic milieu. Despite low CHADS(2) score of 0/1, 6/13 (46.1%) of these patients had a thrombogenic milieu whereas 10/18 (55.6%) patients with score ≥2 had none. The probability of having a thrombogenic milieu did not correlate with the number of clinical risk factors. Conclusion: Among patients younger than 65 years old with atrial fibrillation related to hyperthyroidism, there is no association between clinical risk factors with TEE markers of a thrombogenic milieu. Transesophageal echocardiography adds useful information which may affect antithrombotic therapy guided by clinical risk classification. |
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Authors:
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Marcus Vinicius Leitão de Souza; Martha Maria Turano Duarte; Claudia Medina Coeli; Mario Vaisman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-26 |
Journal Detail:
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Title: Clinical endocrinology Volume: - ISSN: 1365-2265 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0346653 Medline TA: Clin Endocrinol (Oxf) Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd. |
Affiliation:
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Division of Endocrinology, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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