| Atrial fibrillation: from ion channels to bedside treatment options. | |
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MedLine Citation:
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PMID: 19520377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atrial fibrillation is now the most common arrhythmia in clinical practice. Recent understanding of the abnormalities in ion flow that underlie atrial fibrillation has led to the search for new treatment options with improved efficacy and tolerability. The purpose of this article is to review the role of ion channels in the development of atrial fibrillation and discuss the nature of their inhibition by investigational antiarrhythmic agents. Novel treatments include the benzofuran derivative dronedarone, atrial-selective compounds (eg, vernakalant), multichannel blocking agents (eg, tedisamil), and gap junction modifiers (eg, rotigaptide). Targeted antiarrhythmic therapies have the potential to provide safer and more effective management options for patients with atrial fibrillation. |
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Authors:
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Bramah Singh |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-06-11 |
Journal Detail:
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Title: Journal of electrocardiology Volume: 42 ISSN: 1532-8430 ISO Abbreviation: J Electrocardiol Publication Date: 2009 Nov-Dec |
Date Detail:
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Created Date: 2009-10-26 Completed Date: 2010-01-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0153605 Medline TA: J Electrocardiol Country: United States |
Other Details:
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Languages: eng Pagination: 660-70 Citation Subset: IM |
Affiliation:
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David Geffen School of Medicine at UCLA, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA. bsingh@ucla.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Fibrillation
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diagnosis,
physiopathology*,
therapy* Heart Conduction System / physiopathology* Humans Ion Channel Gating* Ion Channels / metabolism* Models, Cardiovascular* |
| Chemical | |
Reg. No./Substance:
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0/Ion Channels |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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