Document Detail

Atrial fibrillation: from ion channels to bedside treatment options.
MedLine Citation:
PMID:  19520377     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation is now the most common arrhythmia in clinical practice. Recent understanding of the abnormalities in ion flow that underlie atrial fibrillation has led to the search for new treatment options with improved efficacy and tolerability. The purpose of this article is to review the role of ion channels in the development of atrial fibrillation and discuss the nature of their inhibition by investigational antiarrhythmic agents. Novel treatments include the benzofuran derivative dronedarone, atrial-selective compounds (eg, vernakalant), multichannel blocking agents (eg, tedisamil), and gap junction modifiers (eg, rotigaptide). Targeted antiarrhythmic therapies have the potential to provide safer and more effective management options for patients with atrial fibrillation.
Bramah Singh
Related Documents :
7880217 - Temporal trends (1975 through 1990) in the incidence and case-fatality rates of primary...
10421597 - Trandolapril reduces the incidence of atrial fibrillation after acute myocardial infarc...
3833917 - Transient atrial fibrillation in a patient with acute ureterolithiasis.
17374347 - Incidence of early adverse events surrounding direct current cardioversion of persisten...
11676947 - Comparison of chronic biventricular pacing between epicardial and endocardial left vent...
12062717 - Sodium accumulation during ischemia induces mitochondrial damage in perfused rat hearts.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2009-06-11
Journal Detail:
Title:  Journal of electrocardiology     Volume:  42     ISSN:  1532-8430     ISO Abbreviation:  J Electrocardiol     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-10-26     Completed Date:  2010-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0153605     Medline TA:  J Electrocardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  660-70     Citation Subset:  IM    
David Geffen School of Medicine at UCLA, VA Greater Los Angeles Health Care System, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Atrial Fibrillation / diagnosis,  physiopathology*,  therapy*
Heart Conduction System / physiopathology*
Ion Channel Gating*
Ion Channels / metabolism*
Models, Cardiovascular*
Reg. No./Substance:
0/Ion Channels

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Preparation and properties of hydroxycamptothecin-loaded nanoparticles made of amphiphilic copolymer...
Next Document:  Left bundle-branch block with right axis deviation-a unique aberrancy during supraventricular tachyc...