Document Detail

Atrial fibrillation and congestive heart failure.
MedLine Citation:
PMID:  19102036     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: The present review will examine the prognostic importance of atrial fibrillation and heart failure, explore the different therapeutic options for treating atrial fibrillation and present the results of the Atrial Fibrillation and Congestive Heart Failure (AF-CHF) trial. RECENT FINDINGS: The Atrial Fibrillation and Congestive Heart Failure trial was a randomized trial involving patients with both atrial fibrillation and heart failure. The trial was designed to compare the maintenance of sinus rhythm with the control of ventricular rate in patients with left ventricular dysfunction, heart failure and a history of atrial fibrillation. There was no significant difference in the rate of death from cardiovascular causes in the rhythm-control group as compared with the rate-control strategy. In addition, there was no significant difference in any of the secondary outcomes including death from any cause, worsening heart failure or stroke. The rate-control strategy eliminated the need for repeated cardioversion and reduced rates of hospitalization. SUMMARY: The results of the Atrial Fibrillation and Congestive Heart Failure trial indicate that a routine strategy of rhythm control does not reduce rate of death and suggest that rate control should be considered a primary approach for patients with atrial fibrillation and heart failure.
Denis Roy; Mario Talajic; Marc Dubuc; Bernard Thibault; Peter Guerra; Laurent Macle; Paul Khairy
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in cardiology     Volume:  24     ISSN:  1531-7080     ISO Abbreviation:  Curr. Opin. Cardiol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8608087     Medline TA:  Curr Opin Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  29-34     Citation Subset:  IM    
Montreal Heart Institute and Department of Medicine, Université de Montréal, Montreal, Quebec, Canada.
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MeSH Terms
Adrenergic beta-Antagonists / therapeutic use
Anti-Arrhythmia Agents / therapeutic use
Anticoagulants / therapeutic use
Atrial Fibrillation / complications,  drug therapy*,  epidemiology
Cardiomyopathies / diagnosis,  etiology
Catheter Ablation
Digoxin / therapeutic use
Heart Failure / complications*,  epidemiology
Heart Rate
Randomized Controlled Trials as Topic
Tachycardia / complications
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Anti-Arrhythmia Agents; 0/Anticoagulants; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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