Document Detail

Atrial fibrillation and coagulation: who and when?
MedLine Citation:
PMID:  19709791     Owner:  NLM     Status:  MEDLINE    
Atrial fibrillation is an independent risk factor for stroke and is also associated with increased mortality above the age of 65 in both males and females. Various factors increase the stroke risk, with the most widely used risk assessment tool being the CHADS2 score which incorporates, heart failure, hypertension, age, diabetes and hitroys of previous stroke or transient ischaemic attack. Despite good evidence for the effectiveness of warfarin in preventing stroke and reducing mortality in atrial fibrillation, there remain a large proportion of patients who do not receive appropriate treatment. All patients with atrial fibrillation should be considered for warfarin therapy aiming for an INR of 2.5. Whilst newer agents may replace warfarin in the future, the evidence for anti-platelet therapy is poor and aspirin should be reserved only for patients who have very low stroke risk or those patients who cannot tolerate warfarin therapy.
David Fitzmaurice
Publication Detail:
Type:  Journal Article; Review     Date:  2009-08-25
Journal Detail:
Title:  Blood reviews     Volume:  23     ISSN:  1532-1681     ISO Abbreviation:  Blood Rev.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-20     Completed Date:  2009-12-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  England    
Other Details:
Languages:  eng     Pagination:  241-4     Citation Subset:  IM    
Department of Primary Care Clinical Sciences, Clinical Sciences Building, The University of Birmingham, Birmingham, UK.
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MeSH Terms
Anticoagulants / therapeutic use
Atrial Fibrillation / complications*
Blood Coagulation* / drug effects
Risk Factors
Stroke / complications*
Reg. No./Substance:

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