Document Detail


Atrial fibrillation is associated with lower cognitive performance in the Framingham offspring men.
MedLine Citation:
PMID:  17904078     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The purpose of this study was to investigate the association of atrial fibrillation (AFIB) with multiple measures of cognitive performance in a large community-based sample extensively characterized for vascular risk factors. Our primary analysis included 1011 Framingham Offspring Study (Framingham, Mass) men, mean age = 61.0 (37-89) years, free of clinical stroke and dementia. Using multivariable linear regression models, we related the presence (n = 59) versus absence (n = 952) of AFIB in men to a global measure of performance and multiple measures of specific cognitive abilities assessed an average of 8 months after the AFIB surveillance period. Adjusting for age, education, multiple cardiovascular risk factors, and cardiovascular disease, men with AFIB exhibited significantly lower mean levels of cognitive performance compared with men in normal sinus rhythm. Men with AFIB exhibited lower performance on global cognitive ability and cognitive abilities including Similarities (abstract reasoning), Visual Reproductions-Immediate Recall, Visual Reproductions-Delayed Recall, Visual Organization, Logical Memory-Delayed Recall, and Trail Making A (scanning and tracking) and Trail Making B (scanning, tracking, and executive functioning). Further studies leading to a better understanding of the mechanisms underlying the relation between AFIB and cognitive performance are important.
Authors:
Merrill F Elias; Lisa M Sullivan; Penelope K Elias; Ramachandran S Vasan; Ralph B D'Agostino; Sudha Seshadri; Rhoda Au; Philip A Wolf; Emelia J Benjamin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association     Volume:  15     ISSN:  1532-8511     ISO Abbreviation:  J Stroke Cerebrovasc Dis     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2007-10-01     Completed Date:  2008-07-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9111633     Medline TA:  J Stroke Cerebrovasc Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  214-22     Citation Subset:  -    
Affiliation:
Statistics and Consulting Unit, Department of Mathematics and Statistics, Boston University, Boston, Massachusetts, USA.
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