| Atrial fibrillation is associated with decreased cardiac sympathetic response to isometric exercise in CHF in comparison to sinus rhythm. | |
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MedLine Citation:
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PMID: 18834463 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The presence of atrial fibrillation (AF) in congestive heart failure (CHF) is accompanied by increased mortality, although the exact mechanism is unclear. In previous studies, we have demonstrated cardiac baroreceptor abnormalities in association with AF and CHF. In this study, we sought to examine the effect of cardiac rhythm on the cardiac sympathetic response to exercise in CHF. METHODS: In 13 CHF patients (six AF, seven SR, left ventricular ejection fraction 31 +/- 2%, age 61 +/- 1 years), we measured the hemodynamic and cardiac sympathetic response isometric handgrip (IHG) exercise. RESULTS: At baseline the groups were well matched. Baseline hemodynamics and cardiac sympathetic activity did not significantly differ between the cohorts. In response to IHG exercise, both groups demonstrated significant hemodynamic responses. In conjunction, the sinus rhythm (SR) group demonstrated a significant increase in cardiac sympathetic response to exercise (P = 0.04) while in contrast the AF group did not (P = 0.6). CONCLUSION: In this study, we demonstrate for the first time that the combination of AF and CHF is accompanied by a marked attenuation of the cardiac sympathetic response to acute hemodynamic stress. This implies AF is associated with a further impairment of baroreceptor response in CHF compared to SR. These findings present possible insights to the associated increased mortality and pathogenesis of AF with CHF. |
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Authors:
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Paul A Gould; Murray D Esler; David M Kaye |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Pacing and clinical electrophysiology : PACE Volume: 31 ISSN: 1540-8159 ISO Abbreviation: Pacing Clin Electrophysiol Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-10-06 Completed Date: 2009-01-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7803944 Medline TA: Pacing Clin Electrophysiol Country: United States |
Other Details:
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Languages: eng Pagination: 1125-9 Citation Subset: IM |
Affiliation:
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Wynn Department of Metabolic Cardiology, Baker Heart Research Institute, Melbourne, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Atrial Fibrillation
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diagnosis*,
physiopathology* Blood Pressure Exercise Test* Female Heart Failure / diagnosis*, physiopathology* Heart Rate Humans Isometric Contraction Male Middle Aged Sympathetic Nervous System / physiopathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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