Document Detail

Atrial fibrillation after aortic arch repair requiring deep hypothermic circulatory arrest: incidence, clinical outcome, and clinical predictors.
MedLine Citation:
PMID:  17544892     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To delineate the incidence, outcome impact, and clinical predictors of atrial fibrillation (AF) after adult aortic arch repair requiring deep hypothermic circulatory arrest (AAR-DHCA) AIMS: To determine the incidence of AF after AAR-DHCA, to determine whether AF after AAR-DHCA affects mortality or stay in the intensive care unit (ICU), to determine multivariate predictors for AF after AAR-DHCA, and to determine whether aprotinin protects against AF after AAR-DHCA. STUDY DESIGN: Retrospective and observational. STUDY SETTING: Single large university hospital. PARTICIPANTS: All adults undergoing AAR-DHCA in 2000 and 2001. MAIN RESULTS: The cohort size was 144. Antifibrinolytic exposure was 100%, aprotinin 66% and aminocaproic acid 34%. The incidence of AF was 34.0%. AF was not significantly associated with increased mortality or prolonged ICU stay. Advanced age was a multivariate risk factor for AF. Lower temperature nadir during DHCA was protective against postoperative AF. Aprotinin had no demonstrable effect on AF after AAR-DHCA. CONCLUSIONS: AF after AAR-DHCA is common but does not independently increase mortality or ICU stay. The risk of AF after AAR-DHCA increases with age but decreases with the degree of hypothermia during DHCA. Aprotinin does not appear to affect the risk of AF after AAR-DHCA.
John G T Augoustides; Wilson Szeto; E Andrew Ochroch; Doreen Cowie; Justin Weiner; Andrew J Gambone; Dawn Pinchasik; Joseph E Bavaria
Publication Detail:
Type:  Journal Article     Date:  2007-02-20
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  21     ISSN:  1053-0770     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-04     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  388-92     Citation Subset:  IM    
Department of Anesthesiology and Critical Care, Hospital of University of Pennsylvania, Philadelphia, PA 19104-4283, USA.
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MeSH Terms
Age Factors
Aorta, Thoracic / surgery*
Atrial Fibrillation / etiology*,  prevention & control
Cardiopulmonary Bypass
Heart Arrest, Induced*
Middle Aged
Multivariate Analysis
Postoperative Complications / etiology*
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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