Document Detail

Atrial dominance in the human embryonic heart - A study of cardiac function at 6-10 weeks of gestation.
MedLine Citation:
PMID:  25484029     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To investigate the difference in forces developed by atrial and ventricular myocardium during contraction in human embryos using a novel method.
METHODS: A cross-sectional study of 115 pregnancies examined at 6-10 weeks of gestation. Ventricular inflow and outflow velocities were obtained by Doppler echocardiography and the relative force development was evaluated by calculating the ratio between atrial and ventricular ejection force (EF).
RESULTS: Data from 97 embryos with monophasic ventricular filling were analyzed. Both inflow and outflow velocities increased with gestational age (p < 0.001). The mean peak inflow velocity (31.7 ± 10.2 cm/s) was higher (p < 0.0001) than outflow velocity (19.6 ± 6.1 cm/s). The EFinflow / EFoutflow ratio was more than 1.0 in all but four ( 96%) cases.
CONCLUSION: Our study indicates the possibility of atrial dominance in the embryonic period of heart development which may have clinical implications, as deviations from this normal pattern may indicate human embryonic cardiac dysfunction.
Agata Wloch; Wioletta Rozmus-Warcholinska; Wojciech Cnota; James C Huhta; Ganesh Acharya
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-8
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  -     ISSN:  1469-0705     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-8     Completed Date:  -     Revised Date:  2014-12-9    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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