| In Vitro Atrial Septal Ablation Using High-Intensity Focused Ultrasound. | |
| | |
MedLine Citation:
|
PMID: 22244000 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: High-intensity focused ultrasound (HIFU) has been applied clinically as a noninvasive therapeutic tool. Atrial septostomy is a palliative treatment for pulmonary artery hypertension. The purpose of this study was to assess the feasibility of atrial septal ablation in vitro using HIFU. METHODS: Fourteen sections of atrial septum from pig hearts were treated. Focused ultrasound energy was applied with an operating frequency of 5.25 MHz at the nominal focal point intensity of 4.0 kW/cm(2) for 0.4 sec in 1-sec intervals. RESULTS: Lesions were created with ultrasonic exposures ranging from 40 to 120 pulses. There were significant relationships between HIFU exposure time and lesion area on the exposed site (R(2) = 0.3389, P < .0001) and lesion volume (R(2) = 0.6161, P < .0001). CONCLUSIONS: HIFU has the potential to create focal perforations without direct tissue contact. This method may prove useful for noninvasive atrial septostomy. |
| | |
Authors:
|
Yasuyoshi Takei; Robert Muratore; Andrew Kalisz; Kazue Okajima; Kohei Fujimoto; Takuya Hasegawa; Kotaro Arai; Yelena Rekhtman; Grace Berry; Marco R Di Tullio; Shunichi Homma |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-1-11 |
Journal Detail:
|
Title: Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography Volume: - ISSN: 1097-6795 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
|
Created Date: 2012-1-16 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8801388 Medline TA: J Am Soc Echocardiogr Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2012 American Society of Echocardiography. Published by Mosby, Inc. All rights reserved. |
Affiliation:
|
Division of Cardiology, Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ejection Fraction Change and Coronary Artery Disease Severity: A Vasodilator Contrast Stress-Echocar...
Next Document: The Incremental Value of Valvuloarterial Impedance in Evaluating the Results of Transcatheter Aortic...