| Atrazine exposure leads to altered growth of HepG2 cells. | |
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MedLine Citation:
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PMID: 21232595 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Atrazine is one of the most commonly used herbicides in the United States. While effective on target plants, it has been associated with harmful health effects in non-target organisms such as fish, amphibians and mammals. In this study, growth effects on human liver cells were determined after exposure to increasing concentrations of this herbicide. Growth of immortalized human hepatoma HepG2 cells was inhibited by atrazine concentrations of 625ppb after 72h exposure and flow cytometry analysis demonstrated HepG2 cells exposed to 100ppb atrazine accumulated in S phase after 48h compared to untreated cells. Expression of cell cycle specific cyclin proteins was altered after atrazine exposure with cyclin E levels significantly decreased after a 24h exposure and cyclin B levels decreased after 48h. This study demonstrates that relatively low levels of atrazine exposure can affect growth and lead to disruptions in the cell cycle regulation of immortalized human liver cells. |
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Authors:
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Erin R Powell; Noha Faldladdin; April D Rand; Daniel Pelzer; Erin M Schrunk; Kavita R Dhanwada |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-11 |
Journal Detail:
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Title: Toxicology in vitro : an international journal published in association with BIBRA Volume: - ISSN: 1879-3177 ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8712158 Medline TA: Toxicol In Vitro Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Biology, University of Northern Iowa, Cedar Falls, IA 50614-0421, United States. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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