Document Detail

Atrazine effects on antioxidant status and xenobiotic metabolizing enzymes after oral administration in peripubertal male rat.
MedLine Citation:
PMID:  22797327     Owner:  NLM     Status:  MEDLINE    
Previously, we reported that in vivo applied atrazine from postnatal day 23 to 50 induced strong inhibition of testicular steroidogenesis. Therefore, the aim of the present study was to investigate, in the same experimental model, the oxidative status in androgen-producing testicular interstitial compartment characterized by diminished steroidogenesis. In parallel, we determined activities of antioxidative and cytochrome P450 (CYP) xenobiotic-metabolizing enzymes in liver. To confirm the results on atrazine induced-inhibition of testicular androgenesis, we measured ex vivo production of androgen in Leydig cells. The results revealed decreased activity of antioxidant enzymes, especially glutathione S-transferase (GST), but also glutathione peroxidase (GSH-Px) and catalase (CAT) in testicular interstitial cells, in parallel with strongly diminished ex vivo basal and agonist-stimulated Leydig cell androgenesis. In liver, atrazine increased the activity of GSH-Px, GST, and CYP1A1/2 enzyme, but not lipid peroxidation. These results indicate that atrazine markedly affects both antioxidant status and androgenesis in peripubertal rats.
Kristina Pogrmic-Majkic; Sonja Kaisarevic; Svetlana Fa; Vanja Dakic; Branka Glisic; Jelena Hrubik; Radmila Kovacevic
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-29
Journal Detail:
Title:  Environmental toxicology and pharmacology     Volume:  34     ISSN:  1872-7077     ISO Abbreviation:  Environ. Toxicol. Pharmacol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-12-05     Completed Date:  2013-06-25     Revised Date:  2014-01-10    
Medline Journal Info:
Nlm Unique ID:  9612020     Medline TA:  Environ Toxicol Pharmacol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  495-501     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Administration, Oral
Atrazine / toxicity*
Catalase / metabolism
Cytochrome P-450 CYP1A1 / metabolism
Cytochrome P-450 CYP2B1 / metabolism
Cytochromes / metabolism
Glutathione Peroxidase / metabolism
Glutathione Transferase / metabolism
Herbicides / toxicity*
Leydig Cells / drug effects,  metabolism
Lipid Peroxidation / drug effects
Microsomes, Liver / drug effects,  metabolism
Rats, Wistar
Testosterone / metabolism
Xenobiotics / metabolism
Reg. No./Substance:
0/Cytochromes; 0/Herbicides; 0/Xenobiotics; 3XMK78S47O/Testosterone; EC; EC Peroxidase; EC protein, rat; EC P-450 CYP1A1; EC P-450 CYP2B1; EC Transferase; QJA9M5H4IM/Atrazine

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