Document Detail


Atracurium after an anticholinesterase. Does prior reversal with edrophonium or neostigmine influence the response to atracurium?
MedLine Citation:
PMID:  8322995     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study documents the response to atracurium (75 micrograms.kg-1) administered 30 min after a pancuronium- or tubocurarine-induced neuromuscular block has been reversed with either neostigmine (50 micrograms.kg-1) or edrophonium (0.5 mg.kg-1). Twenty-one ASA 1 or 2 patients were studied, of whom 11 received neostigmine and 10 edrophonium. The degree of neuromuscular block was measured electromyographically from the first dorsal interosseous muscle of the hand using train-of-four stimulation of the ulnar nerve. When atracrium was administered, the single twitch response compared with control was 100% in all patients and the mean train-of-four ratios were 91% and 65% in the neostigmine and edrophonium groups respectively. After atracurium (75 micrograms.kg-1), minimum values for the single twitch response compared with control were 52% and 66% in the neostigmine and edrophonium groups respectively. Prior administration of atracurium appears to potentiate the neuromuscular blocking effects of atracurium administered 30 min later.
Authors:
G D Shorten; H A Ali
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia     Volume:  48     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1993 Jun 
Date Detail:
Created Date:  1993-08-03     Completed Date:  1993-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  524-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Anesthesia, Massachusetts General Hospital, Boston 02114.
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MeSH Terms
Descriptor/Qualifier:
Adult
Atracurium / pharmacology*
Edrophonium / pharmacology*
Female
Humans
Male
Muscle Contraction / drug effects
Neostigmine / pharmacology*
Neuromuscular Junction / drug effects
Pancuronium / antagonists & inhibitors
Time Factors
Tubocurarine / antagonists & inhibitors
Chemical
Reg. No./Substance:
0/Pancuronium; 312-48-1/Edrophonium; 57-95-4/Tubocurarine; 59-99-4/Neostigmine; 64228-79-1/Atracurium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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