| Atracurium after an anticholinesterase. Does prior reversal with edrophonium or neostigmine influence the response to atracurium? | |
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MedLine Citation:
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PMID: 8322995 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study documents the response to atracurium (75 micrograms.kg-1) administered 30 min after a pancuronium- or tubocurarine-induced neuromuscular block has been reversed with either neostigmine (50 micrograms.kg-1) or edrophonium (0.5 mg.kg-1). Twenty-one ASA 1 or 2 patients were studied, of whom 11 received neostigmine and 10 edrophonium. The degree of neuromuscular block was measured electromyographically from the first dorsal interosseous muscle of the hand using train-of-four stimulation of the ulnar nerve. When atracrium was administered, the single twitch response compared with control was 100% in all patients and the mean train-of-four ratios were 91% and 65% in the neostigmine and edrophonium groups respectively. After atracurium (75 micrograms.kg-1), minimum values for the single twitch response compared with control were 52% and 66% in the neostigmine and edrophonium groups respectively. Prior administration of atracurium appears to potentiate the neuromuscular blocking effects of atracurium administered 30 min later. |
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Authors:
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G D Shorten; H A Ali |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia Volume: 48 ISSN: 0003-2409 ISO Abbreviation: Anaesthesia Publication Date: 1993 Jun |
Date Detail:
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Created Date: 1993-08-03 Completed Date: 1993-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0370524 Medline TA: Anaesthesia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 524-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Anesthesia, Massachusetts General Hospital, Boston 02114. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Atracurium / pharmacology* Edrophonium / pharmacology* Female Humans Male Muscle Contraction / drug effects Neostigmine / pharmacology* Neuromuscular Junction / drug effects Pancuronium / antagonists & inhibitors Time Factors Tubocurarine / antagonists & inhibitors |
| Chemical | |
Reg. No./Substance:
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0/Pancuronium; 312-48-1/Edrophonium; 57-95-4/Tubocurarine; 59-99-4/Neostigmine; 64228-79-1/Atracurium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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