Document Detail

Atoxyl-induced damage to the sensory cells in the organ of Corti in the guinea pig cochlea.
MedLine Citation:
PMID:  824808     Owner:  NLM     Status:  MEDLINE    
Atoxyl-induced damage to the inner and the outer hair cells in the guinea pig cochlea starts in the apical coil and spreads successively downward toward the round window. Vesicular degeneration of both the inner and the outer hair cells and the cell organelles occurs. The degeneration is probably caused by an alteration in ionic composition of the endolymph resulting from primary changes of the stria vascularis (vesiculation and rejection of degenerated marginal and intermediate cells) as reported by Anniko and Wersäll (1975). However, a direct action of atoxyl on the sensory cells of the organ of Corti cannot be excluded.
M Anniko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Virchows Archiv. B: Cell pathology     Volume:  21     ISSN:  -     ISO Abbreviation:  Virchows Arch B Cell Pathol     Publication Date:  1976 Oct 
Date Detail:
Created Date:  1976-12-23     Completed Date:  1976-12-23     Revised Date:  2014-07-21    
Medline Journal Info:
Nlm Unique ID:  0437105     Medline TA:  Virchows Arch B Cell Pathol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  267-77     Citation Subset:  IM    
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MeSH Terms
Aniline Compounds / pharmacology
Arsenicals / pharmacology*
Guinea Pigs
Microscopy, Electron
Organ of Corti / drug effects*,  pathology
Reg. No./Substance:
0/Aniline Compounds; 0/Arsenicals

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