Document Detail


Atovaquone-proguanil: report from the CDC expert meeting on malaria chemoprophylaxis (II).
MedLine Citation:
PMID:  17297027     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The fixed dose combination of atovaquone and proguanil hydrochloride, marketed under the trade name Malarone, is the most recently approved agent in North America for the prevention and treatment of chloroquine- and multi-drug resistant Plasmodium falciparum malaria. In both adult and pediatric populations, atovaquone-proguanil demonstrates consistently high protective efficacy against P. falciparum, and in treatment trials, cure rates exceed 93%. Only a handful of genetically confirmed treatment failures have been reported to date. Atovaquone-proguanil has an excellent safety profile during both prophylaxis and treatment courses, with severe adverse events rarely reported. This topical review will examine the evidence behind the current indications for use of atovaquone-proguanil, and will summarize the current body of literature surrounding safety and tolerability.
Authors:
Andrea K Boggild; Monica E Parise; Linda S Lewis; Kevin C Kain
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Publication Detail:
Type:  Congresses    
Journal Detail:
Title:  The American journal of tropical medicine and hygiene     Volume:  76     ISSN:  0002-9637     ISO Abbreviation:  Am. J. Trop. Med. Hyg.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-02-13     Completed Date:  2007-04-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370507     Medline TA:  Am J Trop Med Hyg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  208-23     Citation Subset:  AIM; IM    
Affiliation:
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada. andrea.boggild@utoronto.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Animals
Antimalarials / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Atovaquone / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Child
Chloroguanide / adverse effects,  pharmacokinetics,  pharmacology,  therapeutic use*
Drug Combinations
Female
Humans
Malaria, Falciparum / drug therapy,  parasitology,  prevention & control*
Male
Plasmodium falciparum / growth & development*
Pregnancy
Randomized Controlled Trials as Topic
Travel
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Drug Combinations; 0/malarone; 500-92-5/Chloroguanide; 94015-53-9/Atovaquone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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