Document Detail

Atorvastatin therapy associated with improvement in left ventricular remodeling in a case of idiopathic dilated cardiomyopathy.
MedLine Citation:
PMID:  17170629     Owner:  NLM     Status:  MEDLINE    
Statins have pleiotropic effects such as anti-inflammatory and vascular protective effects that would be beneficial for patients with chronic heart failure. This report describes a patient with idiopathic dilated cardiomyopathy and a long-standing history of heart failure that was treated with atorvastatin in addition to conventional therapy that included beta-blockers. Atorvastatin therapy for 12 months was associated with an improvement in cardiac function and improved left ventricular remodeling and peak oxygen consumption. This result suggests that statin therapy may be a potential novel treatment strategy for patients with chronic heart failure.
Takahisa Yamada; Koichi Node; Takanao Mine; Takashi Morita; Hidetaka Kioka; Shunsuke Tamaki; Yasumasa Tsukamoto; Masaharu Masuda; Keiji Okuda; Masatake Fukunami
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  332     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-15     Completed Date:  2007-02-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  361-3     Citation Subset:  AIM; IM    
Division of Cardiology, Osaka General Medical Center, Japan.
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MeSH Terms
Anticholesteremic Agents / therapeutic use
Cardiomyopathy, Dilated / drug therapy*
Cardiovascular Agents / therapeutic use*
Heptanoic Acids / pharmacology*,  therapeutic use*
Hypercholesterolemia / drug therapy
Pyrroles / pharmacology*,  therapeutic use*
Ventricular Remodeling / drug effects*
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cardiovascular Agents; 0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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