| Atorvastatin reverses cardiac remodeling possibly through regulation of protein kinase D/myocyte enhancer factor 2D activation in spontaneously hypertensive rats. | |
| | |
MedLine Citation:
|
PMID: 19683055 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was designed to determine whether atorvastatin reduced hypertension-induced cardiac remodeling and whether these effects involved Protein Kinase D (PKD) and Myocyte Enhancer Factor 2D (MEF2D), factors known to be implicated in cardiac hypertrophy and fibrosis. 16-Week-old spontaneously hypertensive rats (SHRs) and age-matched Wistar-Kyoto (WKY) rats were included. Blood pressure and serum lipid concentration were measured. H-E staining, myocardial transverse diameter, and echocardiography were examined to evaluate cardiac hypertrophy. Hydroxyproline content assay and Masson's trichrome staining were used to estimate cardiac fibrosis. Atorvastatin (10, 25 and 50mg/kg/day) was administered for 8 weeks. Increased blood pressure and cardiac remodeling were prominent in SHRs compared with WKY rats. SHRs also had elevated PKD and MEF2D activation. The systolic blood pressure, myocardial transverse diameter and hydroxyproline content were positively correlated with the activation level of PKD and MEF2D in SHRs. Atorvastatin significantly attenuated the activation of PKD and MEF2D. It may be concluded that atorvastatin reverses hypertension-induced cardiac remodeling partially through down-regulation of PKD/MEF2D activation. Our results predict novel therapeutic targets for atorvastatin in treating hypertensive patients. |
| | |
Authors:
|
Jing Geng; Zhuo Zhao; Weiqiang Kang; Wei Wang; Yun Zhang; G E Zhiming |
Related Documents
:
|
9633795 - Increased tissue neutral endopeptidase 24.11 activity in spontaneously hypertensive ham... 2257685 - Effects of calcium and deoxycorticosterone on blood pressure, plasma renin activity and... 17394565 - Nitric oxide, superoxide and renal blood flow autoregulation in shr after perinatal l-a... 7234445 - Distensibility of left atrium in normotensive and spontaneously hypertensive rats. 7271135 - Chronic effects of phasic middle ear pressure changes. 8198625 - No significant effect of calcium and vitamin d supplementation on blood pressure and ca... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-08-13 |
Journal Detail:
|
Title: Pharmacological research : the official journal of the Italian Pharmacological Society Volume: 61 ISSN: 1096-1186 ISO Abbreviation: Pharmacol. Res. Publication Date: 2010 Jan |
Date Detail:
|
Created Date: 2010-02-03 Completed Date: 2010-04-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8907422 Medline TA: Pharmacol Res Country: England |
Other Details:
|
Languages: eng Pagination: 40-7 Citation Subset: IM |
Copyright Information:
|
Copyright 2009 Elsevier Ltd. All rights reserved. |
Affiliation:
|
The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, Shandong 250012, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects Disease Models, Animal Enzyme Activation Fibrosis Heptanoic Acids / pharmacology* Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology* Hydroxyproline / metabolism Hypertension / complications, drug therapy*, enzymology, physiopathology Hypertrophy, Left Ventricular / drug therapy*, enzymology, etiology, physiopathology Lipids / blood Male Myocardium / enzymology*, pathology Protein Kinase C / metabolism* Pyrroles / pharmacology* Rats Rats, Inbred SHR Rats, Inbred WKY Signal Transduction / drug effects Time Factors Transcription Factors / metabolism* Ventricular Remodeling / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Lipids; 0/MEF2D protein, rat; 0/Pyrroles; 0/Transcription Factors; 110862-48-1/atorvastatin; 51-35-4/Hydroxyproline; EC 2.7.10.-/protein kinase D; EC 2.7.11.13/Protein Kinase C |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: beta(2)-Agonist modulates epithelial gene expression involved in the T- and B-cell chemotaxis and in...
Next Document: Functional magnetic resonance imaging of awake behaving macaques.