Document Detail


Atorvastatin and persistent atrial fibrillation following cardioversion: a randomized placebo-controlled multicentre study.
MedLine Citation:
PMID:  19202157     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIMS: To evaluate the effect of atorvastatin in achieving stable sinus rhythm (SR) 30 days after electrical cardioversion (CV) in patients with persistent atrial fibrillation (AF). METHODS AND RESULTS: The study included 234 patients. The patients were randomized to treatment with atorvastatin 80 mg daily (n = 118) or placebo (n = 116) in a prospective, double-blinded fashion. Treatment was initiated 14 days before CV and was continued 30 days after CV. The two groups were well-balanced with respect to baseline characteristics. Mean age was 65 +/- 10 years, 76% of the patients were male and 4% had ischaemic heart disease. Study medication was well-tolerated in all patients but one. Before primary endpoint 12 patients were excluded. In the atorvastatin group 99 patients (89%) converted to SR at electrical CV compared with 95 (86%) in the placebo group (P = 0.42). An intention-to-treat analysis with the available data, by randomization group, showed that 57 (51%) in the atorvastatin group and 47 (42%) in the placebo group were in SR 30 days after CV (OR 1.44, 95%CI 0.85-2.44, P = 0.18). CONCLUSION: Atorvastatin was not statistically superior to placebo with regards to maintaining SR 30 days after CV in patients with persistent AF.
Authors:
Henrik Almroth; Niklas Höglund; Kurt Boman; Anders Englund; Steen Jensen; Björn Kjellman; Per Tornvall; Mårten Rosenqvist
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Publication Detail:
Type:  Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2009-02-06
Journal Detail:
Title:  European heart journal     Volume:  30     ISSN:  1522-9645     ISO Abbreviation:  Eur. Heart J.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-02     Completed Date:  2009-06-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8006263     Medline TA:  Eur Heart J     Country:  England    
Other Details:
Languages:  eng     Pagination:  827-33     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Orebro University Hospital, Orebro, Sweden. henrik.almroth@orebroll.se
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MeSH Terms
Descriptor/Qualifier:
Aged
Anti-Arrhythmia Agents / adverse effects,  therapeutic use*
Atrial Fibrillation / drug therapy*
Double-Blind Method
Electric Countershock*
Female
Heptanoic Acids / adverse effects,  therapeutic use*
Humans
Male
Prospective Studies
Pyrroles / adverse effects,  therapeutic use*
Recurrence / prevention & control
Sweden
Treatment Outcome
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Heptanoic Acids; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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