Document Detail

Atorvastatin and fenofibric acid differentially affect the release of adipokines in the visceral and subcutaneous cultures of adipocytes that were obtained from patients with and without mixed dyslipidemia.
MedLine Citation:
PMID:  22180354     Owner:  NLM     Status:  In-Data-Review    
In this study, we compared the effects of atorvastatin and fenofibric acid, which were administered alone or in combination, on the secretory function of human adipocytes that were obtained from the visceral and subcutaneous adipose tissues of 19 mixed dyslipidemic patients and 19 subjects with a normal lipid profile. The adipocytes were incubated in vitro in the presence of atorvastatin and/or fenofibric acid. The secretory function of the cells was determined using ELISA assays. The visceral adipocytes released significantly more adiponectin and IL-6 and less PAI-1 than those that were obtained from subcutaneous tissue. The levels and patterns of adipokine release differed between the patients with or without lipid abnormalities and between the adipocytes that were obtained from visceral or subcutaneous adipose tissue. The culture that contained hypolipidemic drugs resulted in the significant changes of the release of adipokines. The effects of atorvastatin and fenofibric acid on the hormonal function of human adipocytes may be, in part, responsible for the clinical efficacy of these drugs in the prevention and treatment of dyslipidemia-related cardiovascular and metabolic disorders. The study supports the concept that the pleiotropic effects of fenofibrate and atorvastatin may be, in part, a result of their impact on the secretory function of adipocytes.
Krzysztof Labuzek; Lukasz Bułdak; Anna Duława-Bułdak; Anna Bielecka; Robert Krysiak; Andrzej Madej; Bogusław Okopień
Related Documents :
18962704 - Silver-reductor method for determination of iron in iron ores and iron-ore sinters.
9089804 - The effect of dietary iron deficiency on the fatty acid composition of plasma and eryth...
14751684 - Effect of iron limitation on the growth and cytotoxin production of salmonella cholerae...
1132144 - Studies on non-haemoglobin erythrocyte iron; the influence of haemolysis on plasma iron...
2496664 - 12s,19- and 12s,20-dihydroxyeicosanoids: novel 12s-hydroxy-5,8-cis-10-trans-14-cis-eico...
18543124 - Neurological benefits of omega-3 fatty acids.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacological reports : PR     Volume:  63     ISSN:  1734-1140     ISO Abbreviation:  Pharmacol Rep     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-12-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101234999     Medline TA:  Pharmacol Rep     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  1124-36     Citation Subset:  IM    
Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Medyków 18, PL 40-752 Katowice, Poland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Betulin, betulinic acid and butein are inhibitors of acetaldehyde-induced activation of liver stella...
Next Document:  IFN-? suppresses the high glucose-induced increase in TGF-?1 and CTGF synthesis in mesangial cells.