Document Detail


Atorvastatin does not improve liver biochemistries or Mayo Risk Score in primary biliary cirrhosis.
MedLine Citation:
PMID:  18392679     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Statin treatment reduces hypercholesterolemia and may be anti-inflammatory. Case reports noted decreased alkaline phosphatase and histological improvement following statin treatment in primary biliary cirrhosis. The objective of this study was to assess the long-term effects of statin treatment in primary biliary cirrhosis. A retrospective analysis compared clinical and biochemical data from 15 hypercholesterolemic individuals with primary biliary cirrhosis who were treated long-term with atorvastatin with an age and gender matched, primary biliary cirrhosis control group. A significant decrease in total cholesterol and low-density lipoprotein (LDL)-cholesterol (p < or = 0.002) was observed throughout atorvastatin treatment (median time 2.5 years). LDL-cholesterol levels in the control group were not significantly changed after 2 years (p > 0.050). No significant changes were noted in alanine aminotransferase (ALT), alkaline phosphatase, total bilirubin and Mayo Risk Score in either group (p > 0.05). Long-term atorvastatin treatment reduced LDL-cholesterol in primary biliary cirrhosis, but there was no evidence of any anti-inflammatory effect.
Authors:
Carmen M Stanca; Nancy Bach; Jorge Allina; Carol Bodian; Henry Bodenheimer; Joseph A Odin
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2008-04-05
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-05-28     Completed Date:  2008-08-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1988-93     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, The Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1633, New York, NY 10029, USA. cstanca@lmcmc.com
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MeSH Terms
Descriptor/Qualifier:
Aged
Anticholesteremic Agents / therapeutic use*
Female
Heptanoic Acids / therapeutic use*
Humans
Hypercholesterolemia / complications,  drug therapy*
Lipids / blood
Liver Cirrhosis, Biliary / complications,  drug therapy*
Liver Function Tests
Male
Middle Aged
Pyrroles / therapeutic use*
Quality of Life
Retrospective Studies
Treatment Outcome
Grant Support
ID/Acronym/Agency:
DK59653/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Heptanoic Acids; 0/Lipids; 0/Pyrroles; 110862-48-1/atorvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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