| Atorvastatin attenuates inflammatory infiltration and vascular remodeling in lung of hypercholesterolemia rabbits. | |
| | |
MedLine Citation:
|
PMID: 21043990 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Hypercholesterolemia contributes to cardiovascular diseases, but its direct effect on lung is little known. 3-Hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors (statins) have been shown to exert numerous effects that are dependent and independent of their cholesterol-lowering property. The authors hypothesized that atorvastatin would attenuate hypercholesterolemia-induced lesion in lung. Fifteen rabbits were randomly divided into control group, high-cholesterol forage group, and atrovastatin treatment group. Body weight and blood lipid were measured. All lung tissue and pulmonary arteries were collected for histopathology and immunohistochemistry. Alveolar macrophages (AMs) were cultured and activation of nuclear factor (NF)-κB was detected. Concentrations of interleukin (IL)-6 were measured in serum, bronchoalveolar lavage fluid (BALF), and culture supernatants of AMs. Total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) of high-cholesterol forage group were higher than control group (P < .05). There were infiltrating of AMs and lymphocytes in lung tissue of high-cholesterol forage group. NF-κB activity in AMs and concentrations of IL-6 in serum, BALF, and culture supernatants of AMs were higher than those of control group (P < .01), and so were all vascular remodeling indexes. TC and LDL-C and other indexes of atrovastatin treatment group were decreased (P < .05). Hypercholesterolemia induced pulmonary inflammatory Infiltration and vascular remodeling. Atorvastatin attenuated inflammatory infiltration and vascular remodeling in lung of hypercholesterolemia rabbits. |
| | |
Authors:
|
Shu Duan; Yan Zhang; Shang-jie Wu; Ling-zhi Jiang; Jing Zhang; Yan Gan; Ping Chen; Shui-ping Zhao; Gui-yuan Li |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Experimental lung research Volume: 36 ISSN: 1521-0499 ISO Abbreviation: Exp. Lung Res. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-03 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8004944 Medline TA: Exp Lung Res Country: England |
Other Details:
|
Languages: eng Pagination: 573-92 Citation Subset: IM |
Affiliation:
|
Department of Cardicalogy, Second Xiangya Hospital, Central South University, Changsha, Hunan, PR China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Ozone induces inflammation in bronchial epithelial cells.
Next Document: Uptake of all-trans retinoic acid-containing aerosol by inhalation to lungs in a guinea pig model sy...